然而，当我们再看深一点，问题开始出现了。
However, when we look a bit deeper, problems begin to emerge.
在问题开始出现之前，最近做了更改吗？
Did you implement any recent changes before the problem started appearing?
她认为那是问题开始出现的地方。
随着美元加速下滑，新问题开始出现。
当需要集成时，问题开始出现。
When it comes time to integrate, that's where the problem begins.
然而，我们再看得深一点就发现，问题开始出现了。
However, when we look abit deeper, problems begin to emerge.
然而，由于心血管系统安全问题开始出现，受试者被迫停止服用塞来昔布。
However, subjects had to discontinue taking the drug as concerns about cardiovascular safety began to emerge.
这时，发生了以下情况：抱怨和问题开始出现。“我们为什么不能获得关于X的信息？”
Then it happens: The complaints and questions start to trickle in.
从另一种角度来看，这种转变更为重要，因为这使全新的一类(有可能)没有替代物的问题开始出现了。
In another sense the shift is more fundamental since it opens up a whole new class of (probably) non-equivalent problems.
当人类的活动破坏并加速的自然的温室气体量，人类产生了更多必需的量来维持地球理想温度的气体，问题开始出现了。
The problems begin when human activities distort and accelerate the natural process by creating more greenhouse gases in the atmosphere than are necessary to warm the planet to an ideal temperature.
从2003年起，这一问题开始出现。在1999年高校大幅度扩招以后，四年之后的2003年大学毕业生人数创历史新高。
The problem has been building since 2003, when a record number of students graduated four years after a dramatic expansion of further education in 1999.
这位姓名不详的女子来自山东省，她从7、8岁开始出现咳嗽问题。
The unnamed woman from the province of Shandong started to have coughing problems when she was 7 or 8 years old.
苹果公司在这些问题上的立场是在斯诺登事件出现后形成的，在那之后，公司开始采用了一系列的技术，这些技术在默认情况下将使用者的数据加密，限制他人访问。
Apple's stance on these issues emerged post-Snowden, when the company started putting in place a series of technologies that, by default, make use of encryption to limit access to people's data.
当亚洲的一切似乎都出了问题时，就出现了疯狂推卸责任的现象；现在，当一些事情开始朝着好的方向发展时，就产生了一场争夺信誉的竞赛。
There was frantic blame-shifting when everything in Asia seemed to be going wrong; now there is a race to claim credit when some things have started to go right.
移居国外后，他们的关系开始出现问题了。
The relationship started to go wrong when they moved abroad.
肥胖、心脏病和糖尿病开始出现在以前从未出现过这些问题的人群中。
Obesity, heart disease and diabetes are beginning to appear in a people for whom these have never been problems before.
记忆力减退、做熟悉的任务出现困难、抽象思考出现问题，这些都是疾病开始的征兆。
Memory loss, difficulty in performing familiar tasks, and problems with abstract thinking are all indicators of the beginning of the disease.
更糟糕的是，当亚裔美国人确实开始出现在教科书上的时候，往往会伴随着一些问题。
Worse, when Asian Americans do make an appearance in lesson books, it is often laced with problems.
狩猎、设陷阱和制革等传统技艺开始消失时，身份危机问题随之出现。
There has been a crisis of identity as the traditional skills of hunting, trapping and preparing skins have begun to disappear.
随着时间的推移，他的房子开始出现一些问题。
但是，当到达50K用户时，我们开始观察到运行出现问题。
By 50 K users, however, we started to observe issues with the run.
这并不是大多数人能察觉到的事情，但是一旦你开始思考这个问题，一个崭新的研究空间就出现了。
This isn't something that would occur to most people, but once you start down this avenue of thinking, whole new worlds of inquiry appear.
团队可以使用它来商定并且指定在问题出现时所采取的方法，例如，如果项目开始渐渐的出现问题了，我们将会做什么？
A team can use it to agree on and specify what approach will be taken when a problem arises; for instance, what will we do if the project starts slipping?
假如项目甚至还没有开始之前就出现沟通问题，你想要获得创意的反馈意见或处理难题的建议，那简直跟撞墙一样一点反弹都没有。
If you have problems communicating before the project has even started, you will likely hit a brick wall when trying to get feedback oncreative ideas or dealing with set-backs.
比萨斜塔自1173年开始建造，不久之后就出现了地基不平的问题。
Soon after building started in 1173, the foundation of the Pisa tower settled unevenly.
此前，苹果遭到了一些股东的批评，他们称乔布斯健康问题的披露有限。2004年乔布斯的健康开始出现问题。
Apple has previously drawn criticism from some shareholders over what they have called limited disclosure of Mr. Jobs's health problems, which began in 2004.
随着时间的推进，失业人员自身也开始出现问题：技能的生疏或是不被认可。
Over time, unemployment begins to breed its own problems. Workers may be discouraged or their skills may decay.
随着时间的推进，失业人员自身也开始出现问题：技能的生疏或是不被认可。
Over time, unemployment begins to breed its own problems. Workers may be discouraged or their skills may decay.
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