许多因素影响胰岛移植的预后。
Many factors influence the outcome of islet transplantation.
并结合胰岛移植的应用作了讨论。
Theapplication of islet of langerhans transplantation was discussed.
胰岛移植是治疗1型糖尿病的理想方法。
Islands of Langerhans transplantation is a realistic method to treat type 1 diabetes.
是胰岛移植的糖尿病治疗？
方法将大鼠胰岛移植于糖尿病小鼠肾被膜下。
Methods the islets of rat were transplanted under the kidney capsule of streptozotocin-induced diabetic mouse.
目的：探讨胰岛分离技术和异种胰岛移植排斥反应机制。
Objective: To explore the technique of islet isolation and the mechanism of rejection of islet xenotransplantation.
他是做出正确的选择，不这样做胰岛移植，因为他是很好。
He is making the right choice not to do islet transplantation because he is very well.
目的：如何保护胰岛功能一直是胰岛移植中一个重要的研究内容。
AIM: How to maintain the function of islets is one of important aspects in islet transplantation.
在研究期间，患病的大鼠在胰岛移植前一天开始被注入该制剂两周。
At the time of the investigation, diabetic mice were offered the reagent for two weeks, starting the day before islet transplantation.
结论：趋化因子的上调与巨噬细胞的聚集、胰岛移植物的破坏有关。
Conclusion Upregulated chemokines were associated with macrophage recruitment and destruction of islet xenografts.
研究人员认为，这项结果是胰岛移植治疗1性糖尿病进展的关键一步。
According to investigators, the results are a critical step in the development of islet transplantation as a potential treatment for type 1 diabetes.
结论：胸腺移植对诱导免疫耐受、提高异种胰岛移植物存活有一定作用。
Concluson: Thymus transplantation is effective to induce xenograft tolerance and improve the functional survival time of islet xenograft.
目的研究供体凋亡细胞预输注对大鼠胰岛移植后胰岛移植物功能的影响。
Objective to observe the influence of transfusion of donor apoptotic cells on the function of islet grafts in rat islet transplantation.
目的研究供体凋亡细胞预输注对大鼠胰岛移植后胰岛移植物功能的影响。
To investigate the impacts of cold ischemia preservation time and histocompatibility on the activity of islet cells during the islet transplantation.
胰岛移植已经可以使1型糖尿病患者长期保持血糖正常和非胰岛素依赖。
Islet transplantation has already been able to maintain long-term euglycemia and non insulin-dependence in patients with Type 1 Diabetes.
目的：探讨骨髓间充质干细胞在胰岛移植中对胰岛移植物的潜在保护作用。
Objective: To explore the protection of bone marrow-derived mesenchymal stem cells in the islet transplantation in the potential of islet graft.
虽然结果尚待时日，但是胰岛移植终将成为糖尿病病人的一种有效的治疗选择。
The results of this are awaited, but it appears that islet cell transplantation may yet emerge as an effective treatment option for some members of the diabetic population.
在免疫耐受网络系统的支持下，现在已经开展胰岛移植前瞻性多中心试验研究。
Islet cell transplantation now forms the basis of a prospective multicenter trial under the aegis of the Immune Tolerance Network.
目的评价非糖皮质激素的免疫抑制方案防止大鼠同种异体胰岛移植排斥反应的效果。
Objective To evaluate the effect of anti-rejection of glucocorticoid-free immunosuppressive regimen on allogenic islet transplantation.
是否免疫抑制问题和需要，在未来意味着再次胰岛素的胰岛移植的可能性是不是可行？
Does the immune suppression problem and possibility of needing insulin again in the future mean that islet transplantation isn't viable?
在临床方面，我们分析了胰岛移植的大小对1型糖尿病患者在胰岛素分泌方面的影响。
In the clinical setting, we analyzed the influence of transplanted islet size on insulin production in patients with type 1 diabetes.
目的通过静脉注入抗cd4、CD 8免疫毒素及供体可溶性抗原诱导胰岛移植物免疫耐受。
Objective to induce islet grafting tolerance by intravenous injection of anti CD4, anti CD8 immunotoxins and donor soluble antigen.
连续口服FTY720可有效延长小鼠同种异体胰岛移植物存活时间并呈一定的剂量相关性。
Conclusion Continuous administration of FTY720 can effectively prolong the survival time of islet allograft in mice, which is dose related.
胰岛移植作为治疗糖尿病的一种治疗手段，迄今只能在少部分病人中实施，效果尚难完整评估。
Pancreatic islet cell transplantation as a treatment for diabetes has hitherto been confined to small patient cohorts with limited success.
本文综述了近年来胰岛移植相关研究的进展，包括胰岛的分离、纯化、培养、冷冻保存和免疫隔离；
This paper reviewed recent advances in pancreatic islet transplantation research, including islet isolation, purification, culture, cryopreservation and immunoisolation.
这篇文章综述了埃德蒙德方案提出前后的胰岛移植的结果，包括免疫治疗方案和胰岛供体的相关问题。
This article summarizes the results of islet cell transplantation before and after the advent of the new 'Edmonton protocol 'of immunosuppression and management of the donor pancreas.
胰岛移植可以解决每日胰岛素注射的问题，但供体的有限及免疫排斥反应使糖尿病的治疗受到了限制。
Islet transplantation can solve the problem of daily insulin injections, but the donor's immune rejection and the treatment of diabetes have been restricted.
纳入本研究的患者至少还要再随访一年，以继续评估胰岛移植对患者糖尿病及整体健康情况的影响。
Patients enrolled in the study will be followed for at least another year to continue to assess the effects of the islet transplant procedure on their diabetes and overall health.
因此一个理想的疗法应该具备以下几点：它是一个能防止潜在长期危险和排异反应并无需非特异型免疫抑制疗法的胰岛移植方案。
Thus, an optimal approach would involve an islet transplantation protocol that would prevent graft rejection without the need for potentially dangerous long-term and nonspecific immune suppression.
有几年，治愈的说法看来已经成真了，直到大多的受体中的移植细胞停止产生胰岛素，患者只得重新开始注射。
It looked for a few years like the real deal - until most of the transplanted cells stopped producing insulin in most recipients, and the patients had to resume taking injections.
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