抗生素的广泛使用，导致了大量耐药菌的产生。
Overuse of antibiotics has led to the rapid production of bacteria that are resistant to multiple drugs.
近年来，耐药菌引起的儿童感染已经成了一个大问题。
In recent years the antibiotic resistance of bacteria that cause infections in children has become a major problem.
用脉冲场凝胶电泳对12株耐药菌进行了流行情况分析。
Analysing the outer membrance protien of the 12 strains quinolone isolates with SDS-PAGE electrophoresis, and analysing the spreading trend with PFGE.
干扰细菌间交流的药物比传统的抗生素更不可能产生耐药菌。
Medicines that interrupt communication between bacteria could be less likely than traditional antibiotics to spur the development of drug-resistant bacteria.
因此寻找新的抗耐药菌抗生素已经成为世界亟待解决的问题。
Therefore, it is an urgent problem to be resolve in the world to find new antibiotics against resistant bacteria.
耐药菌株则滋生和扩大，增加了患者今后出现耐药菌感染的风险。
Resistant strains thrive and expand, putting the patient at higher risk of a resistant infection in the future.
应用外排泵抑制剂利血平后，70%诱导耐药菌mic有明显下降。
MIC was decreased by inhibitory of efflux pump in 70% resistant bacteria.
因此，开发新的抗耐药菌大环内酯抗生素已成为当前药物研究的热点。
Therefore, it has attracted extensive attention to develop new potent macrolides against resistant bacteria.
酮内酯类抗生素在对付耐药菌方面作用突出，是最有希望的新型抗菌药物。
Ketolide antibiotics are prominent role in the flight against drug-resistant, and are the most hopeful antibiotic.
细菌也不会再为了生存被迫演化出耐药性，杜绝了产生超级耐药菌的潜在威胁。
Bacteria would then no longer be forced to evolve drug resistance to survive, potentially bringing to an end the scourge of the superbug.
目的：用病例对照研究探讨肝炎肝硬化患者发生多重耐药菌感染的危险因素。
Objective: to make an inquiry into the probable risk factors for antibiotic multi-resistance bacterial infection in patients with liver cirrhosis by case-control study.
本文报道了筛选方法、筛选结果和SP-9299代谢物的抗耐药菌活性。
The metabolite of SP-9299 possesses the activity of multiple anti-methicill…
本文报道了筛选方法、筛选结果和SP- 9299代谢物的抗耐药菌活性。
This paper reported the screening method, results and anti-MRSA activity of SP-9299 metabolites.
结论根据药敏结果合理用药和采取有效的感控措施对防止耐药菌的传播非常重要。
Conclusion It 's very important to use antibiotics reasonably and adopt effective measure to prevent spread of MRS.
全年发生医院感染463例，其中多药耐药菌医院感染208例，占44.92%。
From 463 nosocomial infection cases 208 cases were infected with MDRB, accounted for 44.92%.
因此，基于新靶点设计合成抗耐药菌大环内酯抗生素，是解决细菌耐药性的一条重要途径。
Therefore, design and synthesis of new macrolide derivatives against resistant bacteria based on new target sites is an important way to overcome bacterial resistance.
大环内酯类抗生素耐药菌比例比其他族类抗生素高，在医院环境中表现出最高的耐药菌比例；
Proportion of macrolide antibiotic was higher than other antibiotics and demonstrated the highest proportion in hospitals.
加强血培养病原菌及其耐药性监测，对于合理使用抗菌药物，减少耐药菌产生都有重要意义。
It's necessary to monitor and analyze the bacteria and their resistance for using antimicrobial agents reasonably and reducing the emergence of drug-resistant strains.
过度使用抗生素会导致耐药菌，而这些细菌要得到治愈就必须使用药效更强大，通常也更昂贵的药物。
Overuse of antibiotics can lead to drug-resistant bacteria that have to be treated with more powerful and often more expensive drugs.
结论条件致病菌是感染菌谱中的主要病原菌，多重耐药菌的增多和混合感染是医院面临的重要问题。
Conclusion Opportunistic pathogens were the main pathogens, multiply drug resistant strains and mixed infection were important problems in hospital.
目的：监测重症监护治疗病房患者中分离的革兰阴性杆菌耐药状况，探讨对耐药菌感染的治疗策略。
Objective:To observe the Gram-negative bacterial resistance in patients in Intensive Care Unit(ICU) and to discuss how to treat infections caused by these resistant strains.
由于耐药菌住的出现和传播是治疗结核变得更为困难，并且这也使本病在未来具有更严重的致死性。 。
The emergence and spread of drug-resistant germs makes treating tuberculosis more difficult and could make the disease even deadlier in the future.
生物学活性研究发现，化合物sipi - 763- 1不仅具有抗真菌活性，还具有抗耐药菌的新活性。
The study on biological activity found that compound SIPI 763 1 showed anti fungal activity and new activity against a methicillin resistant Staphylococus aureus.
方法采用回顾性调查和细菌检验鉴定技术，对2008-2010年本医院住院病人耐药菌感染情况进行了调查。
Methods Retrospective investigation and bacteria detection technology were used to investigate drug-resistant bacteria infection from 2008 to 2010.
目的：调查从我院重症监护病房(icu)患者中分离的革兰阴性杆菌耐药状况，并探讨对耐药菌感染的治疗策略。
Objective: to investigate the Gram negative bacterial resistance rates in ICU and discuss how to treat infections caused by these resistant strains.
针对耐药菌日益增多的情况，抗生素已无法达到理想的治疗效果，而噬菌体制剂作为一种新的治疗手段也倍受人们关注。
With the increasing of drug resistance bacteria, antibiotics have not achieved ideal therapeutic efficacy, phagotherapy is attracting more attention from people as a new therapeutic method.
结论：我院通过五年归口管理，降低了原发耐药菌的比例，但仍需进一步加强归口管理力度，从而有效控制原发耐药菌的发生。
Conclusion: The rate of initical drug resistance was reduced in our hospital by concentrative care, but it is necessary to enhance the power in concentrative care in order to control an…
酮内酯中最具代表性的药物泰利霉素已于2001年成功上市，其对包括大环内酯耐药菌在内的革兰氏阳性菌具有良好的抗菌活性。
Telithromycin, which is the representative of ketolides, has come into market in 2001. It shows very good activity against some macrolide-resistant bacteria.
酮内酯中最具代表性的药物泰利霉素已于2001年成功上市，其对包括大环内酯耐药菌在内的革兰氏阳性菌具有良好的抗菌活性。
Telithromycin, which is the representative of ketolides, has come into market in 2001. It shows very good activity against some macrolide-resistant bacteria.
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