通过蛋白酶活性位点丝氨酸残基的磺酰化，不可逆的抑制丝氨酸蛋白酶。
Irreversibly inhibits serine proteases by sulfonylation of the serine residue in the active site of the protease.
本发明属于有机化学技术领域，具体涉及一种胺及其衍生物的磺酰化方法。
The invention belongs to the technical field of organic chemistry, in particular to the sulfonylation methods of an amine and a derivative thereof.
本文综述了磺酰化氮取代氨基酸配合物的合成、配位结构方式的研究进展。
The paper summarizes the progress in the studies of synthesis, coordinated modes of the complexes with N-sulfonyl amino acids.
在制备过程中，对2OH和3 OH的对甲苯磺酰化反应活性差异进行了初步探讨。
The difference in activity between 2-oh and 3-oh for the tosylation reaction has been explored.
最后，研究了叔辛胺和环氧氯丙烷反应得到的1-叔辛基-3-羟基氮杂环丁烷盐酸盐的甲磺酰化和硝化的反应性。
At Iast, the possibility of the 1-tert-octyl-3-hydroxyl azetidine's hydrochloric salt methyl-sulfuric-acyl reaction and nitration reaction is studied.
方法以苯乙酸为原料，经磺化、拆分、酰化、酰胺化和取代五步反应合成头孢磺啶。
METHODS Cefsulodin was prepared, taking phenylacetic acid as the starting material, followed by sulfonation, resolution, acylation, amidation and substitution, in 5 steps totally.
方法以苯乙酸为原料，经磺化、拆分、酰化、酰胺化和取代五步反应合成头孢磺啶。
METHODS Cefsulodin was prepared, taking phenylacetic acid as the starting material, followed by sulfonation, resolution, acylation, amidation and substitution, in 5 steps totally.
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