首先，他们发现，实验小鼠中癌化的肝脏细胞周围的细胞出现了老龄化的症状。
First, they found that the cancerous liver cells in their mice were generally accompanied by cells that had the symptoms of old age.
端粒和端粒酶是现代生物学研究的热点，端粒的缺失与细胞的衰老，端粒酶的活性与细胞的老化及癌化均有密切的关系。
Telomere and telomerase are the focus of modern biological study. There are close relationships among telomere loss and cell ageing, activation of telomerase, cell senescence and immortalization.
巴西一直信奉中间偏左的温和和多元化路线，鲁拉罹癌和DilmaRousseff在2009年罹患淋巴癌的细节都立即公诸于世。
In Brazil, which has espoused a moderate and pluralist vision of the centre-left, the details of both Lula's tumour and Ms Rousseff's cancer of the lymph in 2009 were made public immediately.
嚼食槟榔已知为造成口腔白斑、口腔黏膜下纤维化、口腔癌及食道癌之主要危险因子之一。
The evidence of BQ chewing as one of the major risk factors leading to leukoplakia, oral submucous fibrosis, oral cancer and esophagus cancers have been well published.
复发宫颈癌的治疗应坚持综合与个体化治疗原则。
Furthermore, comprehensive therapy and individualized treatment should be carried out for recurrent cervical cancer.
DNA甲基化可能在肿瘤的早期诊断、预后判断及癌前病变的逆转方面发挥一定作用。
DNA methylation might play a role in the early diagnosis, prognosis judgement and reverse of precancerous lesions of malignant tumors in the future.
方法：应用免疫组化法检测乳腺癌及相应癌旁组织tlr4、增殖细胞核抗原(pcna)的表达，TUNEL法检测组织中细胞的凋亡。
Methods: the expression of TLR4 and PCNA in cancer tissues and adjacent tissues were assessed by immunohistochemical method and the apoptosis was detected by the TUNEL method.
方法对19例肾嫌色细胞癌进行光镜观察、免疫组化研究及随访10~102个月，并复习相关文献。
Methods We examined the microscopic and immunohistochemical features in 19 cases of chromophobe cell renal carcinoma, followed up for 10 ~ 102 months and reviewed related literatures.
目的观察化瘀丸联合TC方案化疗对晚期卵巢癌的疗效及化疗毒副反应。
Objective To observe clinical effects and side reactions of Huayu pill combined with TC (Paclitaxel+Carboplatin) chemotherapeutic regimes on treating epithelial ovarian cancer.
结果支气管类癌尤其非典型类癌若无免疫组化的参与很易误诊为低分化癌或小细胞癌。
Results All the cases with atypical bronchial carcinoid tumor were diagnosed as low differentiation cancer without the help of immunohistochemistry.
甲基化机制可能是肝细胞癌runx3基因失活的重要机制之一。
DNA methylation may be an important mechanism of inactivation of RUNX3 gene in HCC.
方法取人直肠腺癌手术材料30例，用免疫组化方法检测癌区和癌周正常区vegf - C和VEGFR - 3的表达情况。
Methods Specimens were obtained from 30 patients with rectum adenocarcinoma, and examined for the expression of VEGF-C and VEGFR-3 in carcinoma region and normal region.
目的观察鼻咽癌患者放疗后颈部纤维化的情况，探讨影响颈部纤维化的有关因素。
Objective to investigate the post-irradiation neck fibrosis in patients with nasopharyngeal carcinoma and its related factors.
目的检测皮肤基底细胞癌(BCC)中T钙黏蛋白的表达以及异常甲基化。
Objective To detect the expression and aberrant methylation of T-cadherin in cutaneous basal cell carcinoma (BCC).
而癌周肝组织无论是肝硬化或肝纤维化均显示正常肝细胞的酶活性。
The surrounding liver tissue either in cirrhosis or in hepatic fibrosis appeared normal hepatic enzymatic activity.
目的：研究原发性肝细胞癌组织中总基因组DNA甲基化水平及其与病理学及生物学行为的关系。
Objective: To examine the extent of total genomic DNA methylation in hepatocellular carcinoma and the relationship between the DNA hypomethylation. and histopathologic characteristics.
采用免疫组化法检测60例肝癌组织及癌旁肝组织中vegf及MMP - 2的表达，用CD 34标记免疫组化法检测微血管密度(MVD)。
Immunohistochemistry was used to determine the expression of VEGF, MMP-2 in 60 HCC tissues and cancer adjacent tissues, and microvessel density (MVD) was detected with labelled CD34.
目的了解肝细胞癌中blu基因的甲基化状态及临床意义。
Objective to investigate methylation of BLU gene in hepatocellular carcinoma.
结论：（1）等中心面颈联合野设野原则可根据鼻咽癌侵犯的范围做个体化放疗设计。
Conclusions:( 1) Using the design method of block shielding faciocervical portals at isocentre, the individual portals can be designed according to the malignant invading ranges.
方法：运用PCR技术探查67例宫颈癌组织中HPV16感染率，并运用免疫组化ABC法检测HPV16感染对宫颈癌中E7蛋白表达情况。
Methods:PCR was used to detect HPV16 DNA in 67 samples of cervical carcinoma, the protein expression of HPV16 E7 were examined in HPV16 DNA positive samples through immunohistochemical ABC method.
结论肝细胞癌中CHFR基因、EDNRB基因启动子的高甲基化是普遍现象，而3 -OST - 2基因启动子甲基化率较低。
Conclusion promoter methylation of CHFR and EDNRB genes is a common event in HCC, while frequency of promoter methylation of 3-ost-2 is rather low.
方法：应用免疫组化方法检测72例喉鳞状细胞癌组织标本中MMP-2和MMP-9蛋白的表达，并与临床病理特征和预后进行对比。
Methods: Immunohistochemistry was used to examine the expression of MMP-2 and MMP-9 in tissue samples of 72 LSCCs and the results were compared to clinical pathological features and prognosis.
应用放射免疫测定法，对20例胃肠癌患者进行了血清癌胚抗原(CEA)测定，并应用免疫组化法对其中16例癌组织中的CEA进行了检测。
The serum CEA levels were measured by radioimmunoassay in 20 patients with primary gastrointestinal carcinoma. 16 cases were stained for CEA in tissue sections by immunohistochemical technique.
导管原位癌(DCIS)的高发病率和治疗多样化促使人们探究各种治疗的比较效应。
Background the high incidence of ductal carcinoma in situ (DCIS) and variations in its treatment motivate inquiry into the comparative effectiveness of treatment options.
目的探讨鼻咽癌放射性后组颅神经损伤与颈部纤维化的相关性。
OBJECTIVE: To study the relationship between radiation-induced lower cranial neuropathy and neck fibrosis in patients with nasopharyngeal carcinoma.
用免疫组化技术检测了15例正常口腔粘膜、45例癌前病变和21例浸润性鳞癌标本的P53蛋白的表达。
P53 protein expression was studied with immunohistochemically in 15normal oral mucosas, 45 precancerous lesions and 21 invasive squamous cell carcinomas.
PTEN蛋白；细胞外信号调节激酶；鳞状细胞癌；免疫组化。
PTEN protein; extracellular signal-regulated kinase; squamous cell carcinoma; immunohistochemistry.
方法用SP法进行石蜡切片免疫组化染色，检测57例直肠癌组织、46例癌旁组织及20例正常直肠组织中P 16蛋白的表达。
Methods The expression of P16 protein in 57 cases of rectum cancer, 46 cases of adjacent tissue and 20 cases of normal rectum tissue was tested by immunohistochemical SP method.
因此，与upiii相比，UPII对确定尿路上皮起源的癌是一种更有价值的免疫组化标记。
Thus, UPII is a more valuable marker than UPIII in immunohistochemical analyses for confirming the urothelial origin of carcinomas.
应用免疫组化s - P法检测24对食管癌组织及相应正常食管组织中抑癌基因pten的蛋白质表达水平。
Expression levels of PTEN gene were detected by the SP immunohistochemical technique in the selected 24 pairs of tumor tissues and the related normal tissues.
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