泛素化和降解过程涉及一系列蛋白和泛素。
Ubiquitylation and degradation involve a complex set of proteins in addition to ubiquitin.
Hsp70和泛素在细胞中的分布部位一致。
The intracellular localization of HSP70 was consistent with that of ubiquitin.
泛素基因有泛素融合基因和多聚泛素基因两种形式。
The polyubiquitin gene and the ubiquitin extension gene are two kinds of the ubiquitin genes.
泛素蛋白酶体途径是真核生物最普遍的调控过程之一。
The ubiquitin-proteasome pathway is now considered as one of the most common regulatory processes in all eukaryotes.
泛素在目标蛋白上形成多分子长链是多聚泛素化的开始。
Ubiquitin can form chains consisting of several molecules attached to a target protein to form polyubiquitylation.
标记并欺骗诱导过分活化一个被称为泛素化的细胞程序。
Marked for Disposal The trick is played out in a cell process called ubiquitylation.
目的分离、克隆人泛素结合酶基因，并初步研究其组织表达谱。
Objective To identify and clone the gene encoding human ubiquitin binding enzyme and study its expression spectrum.
目的：研究泛素蛋白酶体抑制剂对胃癌细胞增殖和凋亡的影响。
AIM: to investigate effects of ubiquitin-proteasome inhibitor on proliferation and apoptosis of gastric carcinoma cells.
在一些植物病毒和动物病毒中发现了泛素相关蛋白或泛素化病毒蛋白。
Ubiquitin-related proteins and ubiquitined vims proteins have been found in some plant viruses and animal viruses.
已有的研究表明，水稻基因组数据库中存在48个预测的泛素结合酶基因。
Previous studies showed that there are 48 predicted ubiquitin-conjugating enzyme genes in rice genome.
真核细胞使用自噬和泛素蛋白酶体系统，作为它们主要的蛋白质降解通道。
Eukaryotic cells use autophagy and the ubiquitin-proteasome system as their major protein degradation pathways.
研究认为脓毒症大鼠骨骼肌蛋白高分解代谢与泛素-蛋白酶系统密切相关。
Studies suggest that, in sepsis, skeletal muscle protein catabolism and the ubiquitin-proteasome system are closely related.
负责执行这个调控过程的组成成分包括泛素及其启动酶系统和蛋白酶体系统。
Components in charge of this process include ubiquitin, its startup enzymes, and proteasome system.
SUMO分子是一种结构上与泛素相似的分子，它参与蛋白质翻译后修饰。
The small ubiquitin-related modifier(SUMO)family proteins are structurally and mechanistically related to ubiquitin.
泛素系统是近年来新发现的一种蛋白降解途径，在机体代谢调节中起重要作用。
Ubiquitin system is a newly discovered protein degradation pathway in recent years, plays an important role in metabolism regulation.
我们的实验也发现，烧伤脓毒症大鼠骨骼肌内泛素系统的基因和蛋白表达显著增强。
Our study also found that the gene and protein expression of ubiquitin system in skeletal muscle were enhanced during burn sepsis.
CHIP属于连接酶类，具有E3泛素连接酶活性，参与能量代谢途径和新陈代谢。
CHIP, an E3 ubiquitin ligase and cochaperones, involves in energy metabolism and protein quality control.
蛋白结构域分析表明，水稻泛素结合酶基因主要由一个泛素结合酶催化结构域组成。
Protein domain analysis showed that ubiquitin-conjugating enzyme genes mainly consist of a big ubiquitin-conjugating enzyme catalytic domain.
系统进化树分析表明，48个水稻泛素结合酶基因可分为3个大组，总共7个亚组。
Phylogenetic tree analyses indicate that the 48 rice ubiquitin-conjugating enzyme genes can be divided into 3 groups, 7 sub-groups in total.
泛素是一类存在于高等生物的小分子蛋白，可结合到其他蛋白上并改变他们的基本性质。
Ubiquitin, a small protein present in cells of higher organisms, binds to other proteins and influences their fundamental properties.
泛素/蛋白酶体系统在植物的生长发育、形态建成和抗病反应等过程中起着重要的作用。
The ubiquitin / proteasome system plays an important role in plant growth and development, morphogenesis and disease resistance.
泛素- 蛋白酶体途径介导的蛋白降解是机体调节细胞内蛋白水平与功能的一个重要机制。
Protein degradation mediated by ubiquitin-proteasome pathway is an important mechanism which modulates cellular proteins′ activity and function.
泛素缀合途径参与细胞的多种代谢过程，包括DNA损伤修复、细胞周期调控及应激反应等。
The ubiquitin-conjugating pathway involves in numerous metabolic processes in cells, including DNA damage repair, cell cycle control, stress responses and so on.
本文详细介绍了他们的发现，重点介绍了泛素调节下蛋白质降解所需要的各种物质及其机理。
The article introduce their discovery, especially the substances wanted in the course of the ubiquitin-mediated protein degradation and the mechanism.
近年来更多泛素通路被发现，这些通路与经典通路截然不同，因此都称为泛素的非经典通路。
In recent years, many more pathways related to ubiquitin have been found, which is different significantly to the canonical one and called noncannonical pathways.
第一，小泛素相关修饰，或相扑，结合其他蛋白质来改变功能或在细胞内移动它们的物理位置。
The first, Small Ubiquitin-related Modifier, or SUMO, attaches to other proteins to modify their function or physically move them within the cell (SUMOylation).
由磷酸化影响的调控步骤可能与E3泛素连接酶对底物的识别有关，也可能与实际的交联反应有关。
The regulatory step affected by phosphorylation could involve either recognition of the substrate by an E3 ubiquitin ligase or the actual conjugation reaction.
泛素蛋白酶体途径是调节多种细胞生物学过程的重要机制，也是恶性肿瘤相关调节异常的潜在靶点；
Ubiquitin-proteasome pathway is an important mechanism regulating many processes of cellular biology, and also a potential target for abnormal regulation associated with malignancy.
泛素蛋白酶体途径是调节多种细胞生物学过程的重要机制，也是恶性肿瘤相关调节异常的潜在靶点；
Ubiquitin-proteasome pathway is an important mechanism regulating many processes of cellular biology, and also a potential target for abnormal regulation associated with malignancy.
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