具免疫活性的兔模型中缺乏对小鼠细胞异种移植物的免疫反应,表明椎间盘内可能存在尚不为人知的免疫豁免部位。
The lack of immune response to a xenograft of mouse cells in an immunocompetent rabbit model may suggest an as yet unrecognized immunoprivileged site within the intervertebral disc space.
目的探讨异种神经脱细胞移植物桥接大鼠坐骨神经缺损后的神经再生及其再生过程中免疫排斥反应。
Objective To study the regeneration of the defected sciatic nerve of rat repaired by acellular heterogeneous nerve transplant and the immunoreaction after the transplant.
目的综述异种移植物抗宿主反应(GVHD)动物模型的研究现状、检测方法及进展情况。
Objective To review the current condition, test method and progress of the animal model of xenograft versus host disease (xeno GVHD).
目的了解NK细胞和巨噬细胞在T细胞缺乏或T细胞成功重建的情况下对异种移植物排斥的作用。
Objective To evaluate the roles of natural killer (NK) cells and macrophages in the rejection of discordant xenografts in nude mice and T cell-reconstitution nude mice.
目的了解异种移植物抗宿主病(GVHD)的组织学特点,与同种GVHD的区别及异种脾脏移植的关系。
Objective To evaluate the histological characteristics of xenogeneic graft-versus-host disease(GVHD), and to differentiate it from the allogeneic GVHD.
结论:胸腺移植对诱导免疫耐受、提高异种胰岛移植物存活有一定作用。
Concluson: Thymus transplantation is effective to induce xenograft tolerance and improve the functional survival time of islet xenograft.
研究表明,异种移植物引起的延迟性异种排斥反应与内皮细胞活化有关。
In this setting, xenografts elicit severe and acute rejection linked to endothelial-cell activation.
结论:本诱导方案能明显延长异基因异位大鼠心脏移植物存活时间,是便于临床推广应用的一种有效方法,该移植耐受的形成涉及多种机制。
Conclusions: The tolerance induction protocol significantly prolonged cardiac allograft survival in rat, and it appears to be worthy of a clinical trial. This tolerance involved multiple mechanisms.
结论:本诱导方案能明显延长异基因异位大鼠心脏移植物存活时间,是便于临床推广应用的一种有效方法,该移植耐受的形成涉及多种机制。
Conclusions: The tolerance induction protocol significantly prolonged cardiac allograft survival in rat, and it appears to be worthy of a clinical trial. This tolerance involved multiple mechanisms.
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