方法：按《新药审批办法》有关外用药局部刺激性研究的规定进行。
Methods: the methods in the "Approval Provision of New Drug" were used.
本实验显示新型根管充填剂复方牡蛎粉无细胞毒性、无基因毒性、无皮肤致敏性以及局部刺激性，具有良好的生物相容性。
The new root canal filling material showed no detected cytotoxic, genotoxic effect, potential of skin sensitization and topical irritation and has good biocompatibility.
结论该氟片使用方便，局部未见刺激性，可能是临床提高唾液氟浓度、预防龋齿的有效方法，但还需进一步研究。
Conclusion The tablet appears to be a clinically useful means of raising the F- concentration of saliva in the mouth, but further research is needed.
结论该氟片使用方便，局部未见刺激性，可能是临床提高唾液氟浓度、预防龋齿的有效方法，但还需进一步研究。
Conclusion The tablet appears to be a clinically useful means of raising the F- concentration of saliva in the mouth, but further research is needed.
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