目的：合成果胶酮洛芬前药并进行体外评价。
AIM: to investigate the synthesis and colon targeted characteristics of pectin ketoprofen prodrug.
利用凝胶渗透色谱(GPC)测定了前药的分子量。
Gel permeation chromatography (GPC) was used to determine the molecular weight of the prodrug.
按大分子主链分类，介绍了近年来大分子前药的研究进展。
Recent progresses in the studies of macromolecular prodrugs are summarized on types of main chain of macromolecular.
本发明提供单链抗体定向的包含多官能连接基的聚合物前药。
The present invention provides single chain antibody-directed polymeric prodrugs containing multifunctional linkers.
迄今为止每个质子泵抑制剂都被研究开发为一个前药的管理形式。
Every proton pump inhibitor so far developed is administered in a prodrug form.
大分子前药是以大分子化合物为载体的一种新的药物传输体系。
Prodrug is a new drug delivery system based on polymer compounds.
目的探讨腺病毒介导自杀基因联合前药5FC对人胰腺癌的治疗作用。
Objective To determine the efficacy of adenovirus-mediated suicide gene transduction combined with prodrug 5-fluorocytosine (5FC) as a therapeutic protocol for pancreatic cancer.
使用MT4细胞系对合成的高分子前药进行了抗HIV和细胞毒性测试。
The anti-HIV activity and cytotoxicity of the polymeric conjugate were evaluated in MT4 cell line.
对大分子前药的设计与合成，载体、活性药物和连接基的选择进行了论述。
The design and synthesis of macromolecular prodrugs, choice of polymer carrier, active drug and linker are introduced.
本文综述了近年来口服前药研究的进展，主要包括经典前药设计和靶向前药设计。
This review addresses the progress of the oral prodrugs in recent years, mainly including classical prodrug design and targeted prodrug design.
近些年来，许多化学家们对它们进行化学修饰，期望得到高效低毒的抗肿瘤前药。
In recent years, many chemists have modified their chemical structures and hope to develop a better drug to overcome its shortcomings.
前药研究是提高生物药剂学分类系统中第III和IV类药物口服吸收的有效途径之一。
Prodrug is an effective way to improve the oral absorption of the drugs which belong to Biopharmaceuticals Classification System(BCS) class III and IV.
方法：四种药物通过酯化、酰胺反应由不同的连接子合成酰胺类和混合键类互联体前药。
Methods: Amide and mix-type bonds compounds were synthesized by conjugated the amino groups and acid groups with hydroxyl or acid links.
所述可流动组合物包含可生物降解热塑性聚合物，有机液体和利培酮、其代谢物或前药。
The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid, and risperidone, a metabolite, or a prodrug thereof.
前药的接触了强酸后被质子化，并且经过结构的改变成为真正能够抑制质子泵的活化形式。
The prodrug exposed to strong acid is protonated and undergoes a conformational change to its active form which is capable of inhibiting the proton pump.
塞克硝唑苯甲酸酯是塞克硝唑的前药，本文主要对塞克硝唑苯甲酸酯的药理活性进行研究。
Secnidazole benzoate is a former drug of secnidazole, this paper mainly study on the pharmacological activity of secnidazole benzoate.
目的设计并合成单硝酸异山梨酯与阿司匹林组成的孪药，评价该类前药的药理作用和生物活性。
OBJECTIVE to design and synthesize twin drugs of isosorbide mononitrate and aspirin and to evaluate their pharmacological character, hydrolysis and anti-platelet effects.
探讨了前药的体外释药性能，前药系统在中性和酸性磷酸盐缓冲液中均能释放出活性药物分子。
Nanoparticles were well-dispersed with spherical shape, and their surface zeta potentials were slightly positive. The kinetics of hydrolysis for drug delivery system was investigated.
本发明还提供了一种基于树形聚合物肝靶向抗癌纳米前药系统在制备治疗实体肿瘤药物中的应用。
The invention further provides the application of the liver targeting anticancer nanometer prodrug system basing on the dendritic polymer in the preparation of drugs for treating solid tumors.
临床前药代动力学研究是新药开发的重要组成部分，而专属、准确和灵敏的分析方法是其研究的基础。
Preclinical metabolism and pharmacokinetics study is important in drug discovery program and the basis of the study is a specific, sensitive method with good accuracy and precision.
生物还原剂是一种具有肿瘤乏氧靶向性的前药，它会在还原性环境中被还原产生具有细胞毒性的代谢物。
Bio-reductive drugs are pro-drugs that can selectively target the hypoxia cells in tumors. In reductive environment, they are reductively metabolized to generate toxic species.
本发明公开了沙利度胺及其药学可接受的前药、盐、溶剂化物、水合物或包合物的药物组合物和单一单位剂型。
Pharmaceutical compositions and single unit dosage forms of thalidomide and pharmaceutically acceptable prodrugs, salts, solvates, hydrates, or clathrates are disclosed.
综述了喜树碱及其衍生物的小分子、大分子和轭合物前药的研究进展，为新型喜树碱前药的合理药物设计提供一定参考。
The recent progress in low molecular, high molecular and couplet prodrugs of CPTs was reviewed in classified manner, provide a reference for the design of prodrugs of CPTs.
医生可能会开一种或多种治疗经前综合症的药。
Your doctor may prescribe one or more medications for premenstrual syndrome.
我吃的感冒药让我感到昏昏欲睡，所以我只是在睡觉前才吃。
The cold medicine I'm taking makes me drowsy, so I only take it before I go to bed.
他说这是因为他出席前喝了酒吃了感冒药，但是众人皆知他是喝多了。
He says that he had mixed wine and cold medicine before appearing, but he is known to drink heavily.
只是在几十年前认识了其生物性，有了化学杀虫剂和空中撒药之后，人们才开始努力控制这种虫害。
Only when its biology was understood and chemical pesticides and aerial spraying became available a few decades ago, could efforts be made to control the insect.
然而10年前，她被诊为患有慢性阻塞性肺病，那是一种无药可治的恶疾。
But 10 years ago she was diagnosed with COPD, an incurable type of emphysema.
在给你选择一种药物前，你的医生会综合考虑你的健康史，服用减肥药可能造成的副作用以及减肥药与你所服其他药物的相互作用。
Before selecting a medication for you, your doctor will consider your health history, possible side effects and potential interaction of weight-loss drugs with other medications you're taking.
在给你选择一种药物前，你的医生会综合考虑你的健康史，服用减肥药可能造成的副作用以及减肥药与你所服其他药物的相互作用。
Before selecting a medication for you, your doctor will consider your health history, possible side effects and potential interaction of weight-loss drugs with other medications you're taking.
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