Method:Tubulointerstitial fibrosis model was established by unilateral ureteral obstruction(UUO) rat.
方法：采用单侧输尿管梗阻（UUO）诱导大鼠肾小管间质纤维化模型。
Methods The animal model of renal disease was induced by unilateral ureteral obstruction (UUO) in CD-1 mice.
方法采用左侧输尿管结扎的方法建立单侧输尿管梗阻（UUO）雄性CD-1小鼠动物模型。
UUO group rats received an operation with left ureteral obstruction below the renal pelvis and were also gavaged with saline daily;
单侧输尿管梗阻组（U）：大鼠行手术剖腹，分离并于肾盂下结扎左侧输尿管，同时术前一天开始每日给以安慰剂生理盐水灌胃处理；
Objective To investigate the effects of geranylgeranylacetone (GGA) on tubulointerstitiai fibrosis in unilateral ureteral obstruction (UUO) rats.
目的探讨替普瑞酮（GGA）对大鼠梗阻性肾病模型（UUO）肾间质纤维化的影响和可能机制。
Objective To study the protective effects of Shenyankangfu tablet on renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO).
目的：研究肾炎康复片对单侧输尿管梗阻(uuo)大鼠肾间质纤维化的保护作用。
Objective: To study the effects of "Kangxian Ling Decoction" (KLD) on renal interstitial fibrosis induced by unilateral ureteral obstruction (UUO) in rats.
目的：探讨中药抗纤灵方对大鼠单侧输尿管结扎(UUO)所致肾纤维化的防治作用及机制。
To evaluate the effect of estrogen on tubular epithelial cell phenotype transdifferentiation of tubulointerstitial fibrosis in unilateral ureteral obstruction(UUO)rats.
目的探讨雌激素在单侧输尿管梗阻（UUO）大鼠肾间质纤维化模型中对肾小管上皮细胞表型转化的影响。
Estrogen can prevent the development of interstitial fibrosis, the mechanism may with it restrain the tubular epithelial cell phenotype transdifferentiation in UUO rats.
结论雌激素可能通过抑制UUO大鼠肾小管上皮细胞表型转化而发挥延缓肾间质纤维化的作用。
Purpose To observe whether hypoxia exists in the obstructed kidney of unilateral ureteral obstruction (UUO) rat model and its distribution relationship with tubulointerstitial fibrosis.
目的证实结扎致单侧输尿管梗阻(uuo)大鼠模型梗阻侧肾脏是否存在低氧，不同时间点低氧的特点及低氧与肾间质纤维化的关系。
Conclusion the pharmacological effects of curcumin and enalapril may be partly mediated by inhibiting the transdifferentiation of renal tubular epithelial cells towards myofibroblast in UUO rats.
结论姜黄素及依那普利可能通过抑制UUO大鼠肾小管上皮细胞转分化而减轻肾间质纤维化。
Conclusion the pharmacological effects of curcumin and enalapril may be partly mediated by inhibiting the transdifferentiation of renal tubular epithelial cells towards myofibroblast in UUO rats.
结论姜黄素及依那普利可能通过抑制UUO大鼠肾小管上皮细胞转分化而减轻肾间质纤维化。
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