The six-party talks have begun to discuss substantive issue.
六方会谈已开始讨论实质性问题。
On nearly every substantive issue, Obama scaled back American goals and expectations.
几乎在所谈论的每一个实质性问题上，奥巴马都缩减了美国的目标和期望。
The inheritance of property is the most substantive issue in the family relationship. It concerns interests of each kinsfolk.
财产继承往往是家庭继承关系中最实质问题，它关涉到每个家庭成员的切身利益。
The substantive issue must surely be whether Singaporeans have a right to a different view and whether they have effective avenues to express them.
从实质来说，真正的问题是新加坡人是否有权利采取不同的立场，并通过有效的途径加以表达。
If anyone still insists on calling these smaller groups of theories by the simple name, 'consequentialism', this narrower usage will not affect any substantive issue.
如果有人仍然坚持要求这些较小的理论简单的名称的团体，'结果论'，这狭窄的使用不会影响任何实质性问题。
If there's an issue on everybody's minds – address it head-on. Else your audience will be distracted from your substantive content.
如果听众们心中都有一个疑问，那么就先给他们解答，否则他们会无心关注发言的实际内容。
If there's an issue on everybody's minds – address it head-on. Else your audience will be distracted from your substantive content.
如果听众们心中都有一个疑问，那么就先给他们解答，否则他们会无心关注发言的实际内容。
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