The cost of manufacturing a car is substantial and automobile manufacturers spend a significant amount of resources designing the appropriate line for the model of car they are trying to produce.
生产一辆汽车的成本非常可观，并且汽车制造商投入了大量的资源来为他们试图生产的汽车模型设计合适的生产线。
Obesity is a significant public health problem in most developed countries and carries with it substantial morbidity and mortality.
在大多数发达国家，肥胖以及因其产生的高发病率和死亡率，是一个极受重视的社会要点问题。
Searching for a long extent in a fragmented dbspace can take a significant amount of time since a dbspace may contain many small free extents that are searched over; this time can be substantial.
由于需要处理大量的空闲小区段，因此在数据库空间中查找长区段会耗费大量的时间；这种耗费是巨大的。
After retirement there was a substantial drop in rates of both mental and physical fatigue, and a smaller but still significant decrease in depressive symptoms.
退休后，他们的心理和生理疲乏感锐减，抑郁症也相对减轻了不少。
That assertion is controversial, as some doctors aren't convinced that the scientific evidence is conclusive or the potential harm is significant enough to cause substantial concern.
上述言论存在争议，一些医生并不承认这种科学证据具有决定意义或者这种潜在的损害会产生实质性的利害关系。
But significant complexity comes along with this power, to the point that making useful computations exploit even a fraction of the potential of the computing platform is a substantial challenge.
但之而来的是更显著的复杂性，这一点导致的计算机利用甚至一小部分潜在的计算平台都构成了一个很大的挑战。
As regards economy, early studies offered significant advantages since a substantial quantity of interface equipment in the telephone exchange could be eliminated.
至于经济性，早期的研究表明，由于数字业务可以省掉电话交换中大量的接口设备，因而具有重要的优势。
There should be obligations to disclose price sensitive information, deals by directors, changes to significant shareholders and substantial and related party transactions.
申请上市公司应有义务披露价格敏感资料、董事会成员交易、主要股东变动以及重大交易和关联交易。
We provide ongoing access to a substantial network of industry and academic leaders, experienced advisors , and a significant amount of capital and other resources as needed.
我们提供持续获得相当的网络产业和学术带头人，有经验的顾问，以及大量的资本和其他资源的需要。
The FDIC cannot, at this time, determine whether the proposed rule would have a significant economic impact on a substantial number of small entities.
联邦存款保险公司不能在这个时候，确定提议的规则将有重大经济影响相当数量的小实体。
This has had a significant impact on operating costs, reducing staff from about 160 to 100 and enabling the customer to make substantial savings in annual expenditure.
这对运营成本有着重大的影响，使工作人员从160个减少到100个，并让消费者的年度花费得到了实实在在的节省。
What are the most substantial accomplishments from your background? Why do you consider these to be most significant?
您个人背景当中最重要的成就？为什么认为这些成就意义最重大？ 羟。
However, there was significant and substantial heterogeneity between studies.
然而，在这些研究之间存在有显著及大量的异质性。
The only substantial change in the results is that leverage is no longer significant.
独一的本质性的改动，成果是，杠杆率是不再具有很主要的意义。
NEPA litigation does cause substantial delays in a significant number of projects.
依据《国家环境政策法》的起诉的确引起了一些工程实质性的拖延。
This case provides a valuable example that is significant for Chinese substantial investment and development of new low-carbon and renewable energy infrastructure.
这对于中国正推行节约型社会、优化用能结构以及新农村建设具有现实意义。
Pivarnik also noted that continuing the same level of exercise postpartum may not be sufficient to promote significant weight loss, particularly if weight gained during pregnancy was substantial.
Pivarnik还指出，在产后继续做同样水平的锻炼可能不足以促进显着消瘦，尤其是如果在怀孕期间体重上涨是可观的时。
While there has been substantial work accomplished toward the definition of the environmental impact of construction materials, there is significant work still to be accomplished.
尽管对于环境如何影响结构材料的研究已有实质成果，但仍有重要的研究要进行。
Retrospective analyses have demonstrated that significant hepatic necroinflammation and fibrosis were present in a substantial proportion of patients with ALT 1 to 2 x ULN.
回顾性调查显示ALT在1-2倍的正常值的慢乙肝患者中有相当大的比例存在明显的肝脏炎症及纤维化表现。
They don't create a significant risk to life or have a substantial financial impact, and many of them could be resolved by improvements to software and hardware.
而且，闰秒造成的问题中，有很多都将随着软件、硬件的升级得以解决。
They don't create a significant risk to life or have a substantial financial impact, and many of them could be resolved by improvements to software and hardware.
而且，闰秒造成的问题中，有很多都将随着软件、硬件的升级得以解决。
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