We also described the main signaling pathways that regulate the microfilament cytoskeleton.
本文还对调节微丝骨架的主要信号传递途径进行了综述。
However, in a number of human diseases, including cancer, cell signaling pathways can go awry.
然而，许多人类疾病(包括癌症)的细胞信号通路发生错误。
Neurotensin's influence, they found, depends on biochemical signaling pathways inside the cell.
他们发现神经降压素的影响依赖于细胞内生物化学信号途径。
Research has been done on its mechanism, signaling pathways, and potential clinical applications.
人们对其发生机理、信号通路以及潜在的临床应用等方面已作了较多研究。
The fact that therapeutics targeting these signaling pathways are still lagging is not surprising.
事实上，针对这些信号通路的疗法仍然滞后也就不足为奇了。
G protein coupled signal transduction system is one major transmembrane signaling pathways in cell.
蛋白偶联信号传导系统是一类重要的细胞跨膜信号传导途径之一。
However, the mechanisms and signaling pathways involved, in particular in fish, are largely unknown.
然而，其机理和信号传导通路，特别是在鱼中，还知之甚少。
This is an important discovery because - until now - those signaling pathways were not clearly defined.
这是一个重要的发现，因为那些信号途径直到现在仍没有一个清晰的定义。
Key individual components of signaling pathways that control lymphocyte activation have been identified.
个别重点控制淋巴细胞激活的信号通路的组成部分，也已确定。
They found that all three signaling pathways work by inactivating a protein known as BAD that causes cell death.
他们发现这三种信号通路能灭活一种已知的能导致细胞死亡的BAD蛋白。
Most of the proteins were part of signaling pathways, which are key to the body's response to system-wide diseases.
大部分的蛋白质都属于信号传导路径的一部分，身体对于整个系统的疾病所做的反应，这些蛋白质起到关键作用。
Molecular biology proved instrumental in this research, which revealed the different signaling pathways that we now know.
在此研究中分子生物学被证明是有作用的，其揭示了我们现在已知的不同的信号通路。
Our knowledge about the estrogen target cells and exact signaling pathways in the hair follicle is still very limited.
目前对毛囊中雌激素靶细胞和准确信号通路了解甚少。
It is demonstrated that phosphorylation and dephosphorylation of NRs play a critical role in a variety of signaling pathways.
研究表明，核受体的磷酸化与去磷酸化在多条信号途径中起着重要作用。
Electively targeting of signaling pathways using protein kinase inhibitors would have a potential advantage over receptor blockers.
这种用来选择性地阻断信号转导途径的蛋白激酶抑制剂可能是一种潜在的有利的受体阻断剂。
In this review, we discussed FSH signaling pathways and the gene expression changes during Sertoli cell development and spermatogenesis.
文章主要围绕支持细胞中促卵泡素信号途径，及其对细胞发育过程中相关基因表达的影响等方面进行了综述。
Presumably, the abl protein, like the product of many other so-called housekeeping genes, is not essential in normal signaling pathways.
人们推测abl蛋白和其他许多看家基因的产物一样，对于正常的信号转导途径并不是必须的。
GSK3 regulates many functions including cell survival and apoptosis, structure and motility, intracellular signaling pathways and so on.
GSK3底物众多，其功能与细胞的存活与凋亡，结构与能动性以及细胞内众多信号传导通路密切相关。
The main signaling pathways involved are the receptor signaling pathway of T cells, the adhesion molecules, and the cytotoxic effect of NK cells.
涉及的信号通路主要是T细胞受体信号通路、黏附分子、NK介导细胞毒效应等相关通路。
Research of biochemistry and pharmacology in medicine showed that a lot of medicines play their role through G protein coupled signaling pathways.
在有关生化及药理的医学研究中发现许多药剂都是通过G蛋白偶联信号传导途径对动物起作用的。
BackgroundApoptosis is a programed cell death stringently controlled by cell signaling pathways and the expression of pro and anti-apoptotic genes.
细胞凋亡是在基因严密调控下的细胞程序性死亡过程。
These alterations defined a core set of 12 cellular signaling pathways and processes that were each genetically altered in 67% to 100% of the tumors.
这些改变被定义为一组12个核心的细胞信号通路和过程，每个通路在肿瘤有67%到100%的改变。
The team used molecular markers to discover that minocycline very selectively interrupts certain specific signaling pathways critical for T cell activation.
队伍使用分子标志物发现二甲胺四环素非常选择性的阻断T细胞激活的特定专门的信息传导途径。
Here, we give a review on the herbivore-induced signaling pathways resulting in a defense response, the production of volatiles and specific elicitors.
本文重点对虫害诱导的防御反应途径、挥发物的合成、诱导挥发物释放的激发子等进行了综述。
Many signaling pathways play important roles in the formation of mesoderm and patterning of the neuroectoderm during early development of vertebrate embryos.
在脊椎动物胚胎的早期发育中，多种信号途径对中胚层形成和神经外胚层分化起着重要的调节作用。
Genes that are mutated in ovarian cancer, as in other cancers, result in the production of proteins that alter the normal function of signaling pathways in cells.
如同其它癌症，卵巢癌细胞中的基因发生突变，结果产生了能够改变正常信号转导功能的蛋白。
Research on the model organism Drosophila indicate that insect AMPs gene regulation involves multiple signaling pathways and a large number of signaling molecules.
以果蝇为模式生物研究表明，昆虫抗菌肽的基因调控涉及到多个信号通路及大量的信号分子。
Because of their diverse signaling pathways, approximately one third, and perhaps as many as half, of currently marketed drugs are designed to target these receptors.
由于他们多样的信号途径，大约三分之一，也许一半，如今市场上的药物是以这些受体为靶点。
The frog embryo extract and screening strategy may also be applied to identifying compounds that modify other developmentally important signaling pathways, Lee added.
蛙胚提取物和筛选策略还可能应用于鉴定其他对早期发育相关信号通路有影响的化合物。
This review focuses on the signaling pathways mediating the insulin-mimetic and anticancer effects of vanadium compounds, as well as the correlationship between them.
本文对近年来关于钒化合物不同生物效应机制的研究进展进行了总结，着重于其类胰岛素和抗癌效应的信号转导机制以及两者之间的相关性。
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