To accomplish this, Baker and van Deursen designed a fast-aging mouse strain that would, upon receiving a drug trigger, expel p16-producing cells from fatty tissues, muscles and eyes.
为了论证这点，Baker和van Deursen繁殖了一组具有快速衰老基因的实验鼠，在这个过程中，对实验鼠施以药物刺激，从而清除脂肪组织、肌肉和眼睛中含有P16的细胞。
No p16 gene point mutation was detected.
所有标本未检出点突变。
To investigate the expression of p16 in pituitary adenoma.
目的探讨垂体腺瘤中P16蛋白的表达状况。
The second gene, p16, encodes a well known anti-cancer protein.
第二个基因是p 16，编码一种众所周知的抗癌蛋白。
The rate of p16 expression markedly reduced with the increase of clinical stages.
可见p16基因蛋白的阳性表达率随着临床分期升高呈明显下降趋势。
There may exist a mechanism at gene translation level which leads to the inactivation of the p16 and Rb genes.
在翻译水平上也存在着引起基因失活的可能机制。
Then the effects of p16 on the telomeric length, cell morphology, proliferation and cell cycle of MCF 7 cells were measured.
检测其对MCF-7细胞的端区长度、细胞形态、增殖特性及细胞周期的影响。
Please be very careful when you use p16 in this situation, since both dysplastic glands and tubal metaplastic glands will be positive for p16, albeit AIS glands are more diffuse than metaplastic ones.
此时使用p16一定要小心解释，因为异型增生的腺体和输卵管上皮化生的腺体均可p16阳性，尽管AIS比化生者阳性更弥漫。
Conclusions: The over-expression of P16 gene may be involved in ovarian epithelial cancer.
结论：P16蛋白高表达与卵巢癌进展相关。
Conclusions The expression of VEGF, P53, and P16 was correlated with glioma malignant degree.
结论VEGF、P 53、P16在胶质瘤中的表达与其恶性程度相关。
Method: By S - P immunohistochemistry method, 60 cases were marked by P16 multiclonal antibody.
方法：应用P16多克隆抗体对60例肝癌用S-P法进行免疫组织化学标记。
Purpose: To study the association of P16, VEGF and MVD with the biological behavior of human breast cancers.
目的：为研究多肿瘤抑制基因（p16）、血管内皮生长因子（VEGF）和肿瘤毛细血管密度（MVD）与乳腺癌生物学行为的关系。
Objective: To investigate the correlation of P16 protein expression in breast carcinoma with clinical stage.
目的：研究p 16蛋白在乳腺癌的表达及与临床分期的相关性。
The expression location of P16 protein could be a characteristic for identifying benign and malignant tissue.
P16蛋白的表达部位对良性及恶性病变可能具有鉴别意义；
The detection of P16, PCNA can evaluate the malignant degrees and may predict prognosis of ovarian carcinoma.
P 16和PCNA的检测可作为判断卵巢癌恶性程度和预测预后的参考指标。
Expressions of COX-2, P16 and HGF were detected by immunohistochemical method in 50 samples of gastric tissues.
对所有50例胃组织腊块运用免疫组化方法检测COX-2、P16和HGF蛋白表达情况。
CONCLUSIONS: positive and strongly positive expression of P16 in ca tissue implied risk of cancerization of ca.
结论：尖锐湿疣患者P 16蛋白阳性或强阳性表达提示有癌变的可能。
Objective To investigate the significance of P16 protein immunohistochemistry detection in in pediatric gliomas.
目的探讨P16蛋白免疫组织化学检测在小儿脑胶质瘤中的意义及其应用价值。
To study the expression of PTEN, EGFR and P16 protein will build up target gene therapy foundation of astrocytoma.
通过对PTEN、EGFR、P 16蛋白的表达研究，为肿瘤的靶基因治疗策略提供了理论依据。
Methods Immunohistochemical staining was used to determine the expression of P16 and P53 in 36 cases of retinoblastoma.
方法对36例视网膜母细胞瘤标本采用免疫组织化学方法观察P 16和P 53表达水平。
Objective:To study the expression of P16 protein and PCNA in ampullary carcinoma and its relation with its pathological features.
目的：探讨壶腹癌中抑癌基因P16蛋白与增殖细胞核抗原（PCNA）表达的相关性及其与肿瘤临床病理特征的关系。
The positive frequency of methylation of P16 gene promoter in HPP-CFC of normal contrasts was higher than that of psoriatic patients.
正常对照骨髓HPP-CFCP16基因启动子甲基化阳性率较高，而银屑病患者骨髓HPP-CFC P16基因启动子甲基化阳性率低于正常人。
Objective: To explore the alteration and the possible mechanism of tumor suppressor gene P16 in the progression of ovarian carcinoma.
目的：探讨卵巢癌病变中P16抑癌基因的改变和可能的作用机制。
Purpose:Find the relationship between the expressions of P21 oncogene, P16 antioncogene and the biological action of the bladder cancer.
目的：探讨癌基因P2 1和抑癌基因P16的表达与膀胱癌生物学行为之间的关系。
Objective To study the expression of P63 and P53, the relation between the expression of P63, P53 and PCNA, P16 in pancreatic neoplasms.
目的研究P53、P 63基因在胰腺肿瘤中的表达及其意义；P 63基因表达与P 53、增殖细胞核抗原(pcna)、P 16表达的关系及其意义。
Objective: to determine the expression of CDK4 and P16 and its relation to the clinicopathological characteristics in some epidermal tumors.
目的：探讨CDK4、P 16在某些表皮肿瘤中的表达及其与临床病理特征的关系。
Objective To observe the expression of cyclin kinase inhibitor P16 in pterygium and to investigate its effects on the pathogenesis of pterygium.
目的探讨翼状胬肉组织中细胞周期蛋白依赖性激酶抑制剂P16的表达，了解其在翼状胬肉发病机制中的作用。
Objective to investigate the relationship between the expression of P16 and P53 in brain astrocytoma with their grading of pathological histology.
目的探讨P 16和P 53蛋白的表达与脑星形细胞瘤的病理组织学分级的关系。
Objective to investigate the relationship between the expression of P16 and P53 in brain astrocytoma with their grading of pathological histology.
目的探讨P 16和P 53蛋白的表达与脑星形细胞瘤的病理组织学分级的关系。
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