Objective To discuss the mechanism of age-related the osteoblast and osteoclast differentiation from marrow cells and discuss the mechanism of aged bone loosing disease.
目的从骨髓细胞分化角度研究年龄相关的成骨和破骨细胞分化的机理，探讨老年性骨质疏松症的发生机理。
Results RAW264. 7 cells show TRAP-negative with monocyte or 2 nucleus, expressing osteoclast phenotypic and functional genes without capability of absorbing bone tissue.
结果raw264.7细胞TRAP染色阴性，单核或2个核，能表达破骨细胞表型和功能基因，无骨吸收功能。
Postmenopausal osteoporosis is a kind of metabolic osteopathy, whose cause is that bone absorption of osteoclast is more forceful than osteogenesis of osteoblast.
绝经后骨质疏松症是一种代谢性骨疾病，是绝经后妇女雌激素水平降低导致破骨细胞的骨吸收大于成骨细胞的骨形成作用。
The inhibition of the differentiation and maturity of osteoclast will inhibit bone resorption.
抑制破骨细胞的分化成熟就能有效控制骨的吸收。
Conclusions Osteoclast-mediated bone resorption was inhibited by the bisphosphonate administration.
结论双膦酸盐对破骨细胞性骨吸收有明显的抑制作用。
Moreover, Er-xian decoction obviously reduced osteoclast number(P<0.01)and enhanced bone density of femur metaphysis in ovariectomized rats(P<0.05).
减少破骨细胞数（P<0.01）且显著增加去卵巢大鼠股骨骨密度（P<0.05）。
Summary of Background Data. Osteopetrosis is characterized by osteoclast dysfunction, impaired bone resorption, and poor bone remodeling.
石骨症的特征是破骨细胞功能出现障碍，使骨吸收减慢，导致骨再建缺陷。
Results: Caseification, osteoclast hyperplasia and bone destruction were found in the location of Mt sonicate injection.
结果：观察显示，结核因子注射部位出现干酪性坏死，破骨细胞数量增加，骨质破坏明显。
Results The trabecular bone volume and mean cortical thickness decreased in OVX, however, the number of osteoclast were higher than normal rats.
结果：去势大鼠骨组织皮质及骨小梁变薄，骨矿化率增高，矿化缘长度增加，小梁表面破骨细胞数明显增多。
The activity between the osteoblast and the osteoclast, with their mutual effects, influence the procedure of bone remodeling.
成骨细胞与破骨细胞间的活动及其相互作用共同影响着骨改建的过程。
Its physiological function was to combine osteoclast differentiation factor, restrain the proliferation and activation of osteoclast and protect bone from losing bone mass.
其生理作用是与破骨细胞活化因子结合，抑制破骨细胞增殖和活化，防止骨质丢失。
If the alveolar bone resorption can be controlled through inhibition of osteoclast, the anchorage teeth movement will be effectively managed.
如果能够控制破骨细胞的产生从而控制牙槽骨的吸收，就可以达到控制牙齿移动的目的。
If the alveolar bone resorption can be controlled through inhibition of osteoclast, the anchorage teeth movement will be effectively managed.
如果能够控制破骨细胞的产生从而控制牙槽骨的吸收，就可以达到控制牙齿移动的目的。
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