ObjectiveTo determine the optimal extracting process of oridonin.
目的确定冬凌草中冬凌草甲素的最佳提取工艺。
Objective To study the inhibition of Oridonin on DNA damage in the mammalian cells.
目的探讨冬凌草甲素对哺乳动物细胞DNA损伤的抑制作用。
Conclusion Oridonin has significant inhibition on DNA damage in the mammalian cells.
结论冬凌草甲素具有明显的抑制哺乳动物细胞DNA损伤的作用。
After recrystallizing the oridonin content is determined by TIC Scanning to be as high as 99.28%.
经重结晶后用薄层扫描法测定含量达99.28%，是一种简便易行的方法。
Conclusion the apoptosis of PC-3 cells induced by oridonin might be associated with the mitochondrial pathway.
结论：冬凌草甲素可能通过线粒体途径诱导PC - 3细胞凋亡。
Objective: to study the mechanisms of oridonin-induced U937 cell apoptosis, and to examine the role of ERK MAPK.
目的：研究冬凌草甲素诱导人组织淋巴瘤u 937细胞凋亡的机制及ERK激酶在凋亡过程中的作用。
CONCLUSION Oridonin loaded stearic acid solid lipid nanoparticles were produced with stable physical properties.
结论冬凌草甲素可以制成硬脂酸纳米粒，各项物理指标稳定。
Results: Oridonin could decrease the activity of telomerase, as well as cause apoptosis and inhibit the growth of K562 cells significantly.
结果：冬凌草甲素可显著降低K5 6 2细胞的端粒酶活性，抑制细胞的生长，诱导细胞发生凋亡。
Objective to investigate the mechanism of cell growth inhibition and apoptosis inducement of oridonin on human hepatocellular carcinoma BEL-7402 cells.
目的探讨冬凌草甲素体外对肝癌BEL- 7402细胞生长抑制作用及诱导细胞凋亡作用机制。
Oridonin anent-kaurene diterpenoid compound mainly isolated from the leaves of R. rubescen. Oridonin has been proved to possess good antitumor activity .
冬凌草甲素是从冬凌草等植物叶子中提取出的一种贝壳杉烯二萜类化合物，具有好的抗肿瘤活性。
Conclusion microwave technology for oridonin extraction has advantages of rapid extraction, simple operation, saving solvent and higher extraction yield, etc.
结论采用微波萃取技术提取冬凌草甲素，具有提取快速、操作简便、节省溶剂和有效成分提取率高等优点。
OBJECTIVE To optimize the preparation method of the oridonin-loaded polylactic-acid nanoparticles, and investigate its properties and release behavior in vitro.
目的优化冬凌草甲素聚乳酸纳米粒的制备工艺，并对其理化性质和体外释药特性进行考察。
The invention belongs to the medicine technology field, which provides an oridonin a polymer micelle drug delivery preparation and a preparation method thereof.
本发明属于医药技术领域，提供一种冬凌草甲素聚合物胶束给药制剂及制备方法。
Methods apoptosis and morphology variations were investigated by microscopic inspection and flow cytometry (FCM). Results Oridonin can induce HCT8 cell apoptosis.
方法利用光镜及流式细胞仪观察不同浓度冬凌草甲素诱导结肠癌hct8细胞凋亡的作用。
Methods:After PC-3 cells were incubated with different concentrations of Oridonin, (1) the metastasis ability was analyzed with experiment of chemotaxic migration;
方法：用不同浓度的冬凌草甲素作用于PC-3细胞，用体外驱化运动试验检测PC-3细胞运动驱化能力的变化；
In our study, we observe whether Oridonin suppresses proliferation, induces apoptosis and inhibits metastasis of PC-3 cells and to explore its possible mechanisms.
第一章冬凌草甲素对PC - 3细胞的增殖抑制效应目的：确定冬凌草甲素是否具有抑制PC - 3细胞增殖的能力。
Results To determine the Oridonin extracted from diethyl ether of plasma by RP-HPLC method, the retention time was stable, the linear curve fitted well, and the results were accurate and reliable.
结果RP - HPLC法测定乙醚萃取的血浆中冬凌草甲素保留时间稳定，标准曲线线性良好，结果准确、可靠。
Results To determine the Oridonin extracted from diethyl ether of plasma by RP-HPLC method, the retention time was stable, the linear curve fitted well, and the results were accurate and reliable.
结果RP - HPLC法测定乙醚萃取的血浆中冬凌草甲素保留时间稳定，标准曲线线性良好，结果准确、可靠。
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