This study was to evaluate the effect of MTHFR C677T polymorphism on chemosensitivity and toxicity to 5 FU in patients with gastric carcinoma.
本研究旨在观察mthfr基因C677T多态性对预测胃癌患者对5 -FU的敏感性和化疗毒性的影响。
Results : Detection of MTHFR gene C677T polymorphism was quickly finished by realtime fluorescence quantitative RT - PCR, and the results were proved to be effective by PCR - RFLP.
结果：荧光定量方法可以快速完成MTHFR C677T基因多态性的检测，检测结果得到传统PCR-RFLP方法的证实。
Objective To explore relationship between methylenetetra hydrofolate reductase (MTHFR) polymorphism and neural tube defects (NTDs)of women in the northern countryside.
目的探讨北方乡村妇女亚甲基四氢叶酸还原酶（MTHFR）基因多态性与神经管畸形的关系。
Conclusion: MTHFR A1298C polymorphism may be associated with reduced risk of rectal cancer, and MTHFR C677T polymorphism with enough folic acid intake may be a protective factor of colon cancer.
结论：MTHFR A 1298 C位点多态性是直肠癌的保护因素，在叶酸摄入充足的条件下，MTHFRC677T多态是结肠癌的保护因素。
Methods: PCR-RFLP technique was used for detecting the A677V polymorphism site of MTHFR gene.
方法：运用多聚酶链反应-限制性内切酶片段长度多态性技术(PCR -RFLP)检测MTHFR的677位点多态性。
Methods: PCR-RFLP technique was used for detecting the A677V polymorphism site of MTHFR gene.
方法：运用多聚酶链反应-限制性内切酶片段长度多态性技术(PCR -RFLP)检测MTHFR的677位点多态性。
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