We hypothesize that inside-outside transport of leukotriene C4 (LTC4) via MRP1 is a substantial proatherogenic mechanism in the vasculature.
我们假设多药抗药性相关蛋白-1介导的白三烯C4内位-外位转运是致血管系统动脉粥样硬化的重要机制。
Results Compared with the control group, MRP1 expression in brain specimens of medically intractable epilepsy patients showed an obviously statistical increasing(P<0.01).
结果药物难治性癫痫患者组脑内MRP1的表达显著高于正常对照组（P<0.01）。
Conclusions-: These findings indicate that MRP1 and LTC4 exert proatherosclerotic effects and that both MRP1 and LTC4 are potentially promising targets for atheroprotective therapy.
结论—这些研究结果表明多药抗药性相关蛋白-1和白三烯C4都有致动脉粥样硬化作用，因此两者都有可能成为抗动脉粥样硬化治疗的靶向物质。
Conclusion Altered subcellular distribution of DNR in resistant cell line was related to MDR gene formation. Quercetin could inhibit MRP1 function and could restore the subcellular DNR distribution.
结论DNR在耐药细胞中的异常分布与肿瘤细胞耐药基因形成有关，槲皮素在体外直接抑制MRP1功能，恢复DNR在细胞内的分布。
Conclusion Altered subcellular distribution of DNR in resistant cell line was related to MDR gene formation. Quercetin could inhibit MRP1 function and could restore the subcellular DNR distribution.
结论DNR在耐药细胞中的异常分布与肿瘤细胞耐药基因形成有关，槲皮素在体外直接抑制MRP1功能，恢复DNR在细胞内的分布。
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