Dysregulation of these core pathways and processes through mutation can explain the major features of pancreatic tumorigenesis.
由于突变而引起的这些核心通路和调节过程的失调，是胰腺癌形成的主要特征性改变。
Somatic mutation, a main biological phenomenon of citrus and other fruits, is often used for breeding as a major variation source. Spontaneous mutations often occur in citrus.
体细胞突变是柑橘等果树比较常见的生物学现象，也是品种选育，即芽变选种的主要变异来源。
Conclusions No functional FANCA protein was found in these 3 cases of FA-A, and intragenic deletion, frame shift and splice site mutation were the major pathogenic mutations found in FANCA gene.
结论3例FA-A型患者均无功能性FANCA蛋白表达；基因缺失、移码突变和剪切位点突变是FANCA基因的主要失活方式。
Therefore mutation of insulin gene promoter might not be a major genetic factor for type 2 diabetes mellitus in Chinese patients.
结论：胰岛素基因启动子突变可能不是中国人2型糖尿病的重要遗传因素。
The result reveals that I164T mutation is not a major predisposing genetic factor for type 2 diabetes and the mutation in adiponectin gene is different in rac…
提示I164T突变可能不是本组2型糖尿病的重要遗传因素，且该基因位点突变具有种族异质性。
The results showed that the major cause of thread gluing is over plastic deformation of partial thread face, and that the distribution of contact stress can be improved with the taper mutation, wh...
认为产生粘扣的主要原因是螺纹齿面局部过量的塑性变形，通过变锥度的方式能使接触应力分布规律得到改善，并在现场生产中得到验证。
The results showed that the major cause of thread gluing is over plastic deformation of partial thread face, and that the distribution of contact stress can be improved with the taper mutation, wh...
认为产生粘扣的主要原因是螺纹齿面局部过量的塑性变形，通过变锥度的方式能使接触应力分布规律得到改善，并在现场生产中得到验证。
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