Ligand binding induces multimerization, autophosphorylation, and activation of these receptors (3-5).
配基的结合诱导多聚化、自磷酸化和相应受体的激活[3 - 5]。
The mutant TSHRs show reduced or no function because of either altered ligand binding or defect in membrane expression.
突变受体功能下降或丧失是由于与配体结合改变或在膜上表达缺陷。
There's a diverse range of responses that might occur, but that response is initiated by this simple chemical process of a ligand binding to a receptor.
细胞对外界信号可能会发生不同的反应，但这些反应都源自，配体和受体结合这个简单的化学过程。
Maximal binding volume of glucocorticoid receptor (GR) in hepatic tissue was assayed by radio-ligand binding assay and protein content was assayed by Western blot.
肝组织GR采用放射性配体结合分析法测定其最大结合容量以及用免疫印迹法测定其蛋白含量。
With certain caveats, changes in flexibility that occur upon ligand binding, mutation, or changes in sample conditions can be interpreted in terms of contributions to conformational entropy.
与某些变数，变化的灵活性，发生在配体结合，突变，或改变抽样条件可以解释方面的贡献，构象熵。
As with chromatographic methods, microbiological and ligand-binding assays should be shown to be selective for the analyte.
正如色谱法，微生物和配体结合分析应体现分析的选择性。
The protein has multiple subunits, each with a single ligand-binding site. Binding of ligand to one site decreases the binding affinity of other sites for the ligand.
此蛋白质有多个亚基，每个亚基上有一个结合位点。配体与一个结合位点的结合降低了其它位点对配体的亲和力。
They are very similar in structure, but different in tissue distribution, expression in different tissues and biological effects after binding to ligand.
两种亚型在结构上有高度的同源性，但是组织分布和各组织成分中的表达明显不同，与配体结合后产生的生物效应也不同。
The purpose of the paper is to build a module of small molecular receptor fragments charactering normal VLDL-R binding function and study the mechanism of VLDL-R binding to ligand.
建立具有正常极低密度脂蛋白（VLDL）受体结合功能的小分子受体片段模型并借助此模型研究VLDL受体与配体结合的作用机制。
Optimal conditions for receptor binding analysis system were established by unlabeled ligand saturation experiment.
通过非标记配基饱和实验建立理想的受体结合分析系统。
Objective to determine fine binding site of ligand to fibroblast growth factor receptor 1 (FGFR1).
目的确定人成纤维细胞生长因子受体1 (FGFR1)的配体精细结合位点。
The binding ability of new peptide ligand GE11 and epidermal growth factor receptor (EGFR) was analyzed by affinity capillary electrophoresis (ACE) method.
应用亲和毛细管电泳(ace)分析方法，对表皮生长因子受体(EGFR)和新多肽配体GE11之间的结合能力进行分析。
Binding of ligand to one site decreases the binding affinity of other sites for the ligand.
配体与一个结合位点的结合降低了其它位点对配体的亲和力。
Starting from the metal complexes solution structures, this paper analysizes the ligand chemistry of metal centers such as iron and cobalt and binding of aminocarboxylate and thiochelate complexes.
从金属络合吸收剂的结构出发，分析了铁、钴等金属中心离子和氨基羧酸类或巯基类配体的配位化学；
On the contrary, TM4 is assumed to playa key role in the ligand-binding for the high variability.
相反TM4可变性很高，所以我们推测TM4可能在配基结合中起关键的作用。
The binding ability and binding domain of receptor to ligands were determined by radioactive ligand and receptor binding experiments.
用放射性受体结合实验进行受体活性的测定和结合区域的分析。
The NGR peptide is a ligand specifically binding to tumor angiogenic blood vessels, and thus has potential usage in the diagnosis and therapy of tumor.
天门冬酰胺酰甘氨酰精氨酸(NGR)是特异性地定位于肿瘤新生血管受体的多肽基序，在肿瘤诊断和治疗方面具有潜在的应用前景。
TM3, TM5 and TM7 are highly water-soluble and considered as the ligand-binding sites as showed by the analysis of its hydrophobicity.
从疏水性分析来看，TM3、TM5与TM7在整体上是高度亲水的，推测可能是配基直接结合区域。
The first part of the thesis describes the expression and characterization of the human insulin receptor's ligand-binding domains L1 and L2.
第一部分阐述了人胰岛素受体配基结合结构域L1和L2的可溶性表达并鉴定了它们的配基结合能力。
The binding of protein with its ligand can be generalized into two major modes: direct binding with surface loops or binding associated with hinge movement.
蛋白质分子与配体的作用模式主要有直接的环区结合及铰链式结合两种方式。
Some kinds of receptors possess two affinity binding sites, they belong to the complex ligand-binding system.
某些受体存在着亚型或异质型，即对某种配基存在有亲和性不同的结合部位，属复杂配基—结合系统。
The binding mode of the ligand was completely preserved when the complex was prepared with the ligand.
由配体形成配合物时，配体上原来成键模式完全保留了下来。
The principal question in drug design is how to study the ligand-binding sites and others because of the poor structure information.
如何在生物胺受体结构数据严重匮乏的基础上研究受体的配基结合位点及其它功能位点，已成为药物设计中的关键问题。
Because the binding of the neurotransmitter (ligand) to the receptor activates these ion channels, they are called ligand-gated channels to distinguish them from voltage-gated channels.
因为神经递质和受体结合（配位）启动了这些离子通道， 所以他们被称为配位门通道，以区别于电压门通道。
Molecular dynamics simulation and thermodynamic integration method were used to calculate the absolute binding free energy of the protein- ligand complex.
介绍了用分子动力学模拟与热力学积分法相结合 ，模拟蛋白质与配体的绝对结合自由能的方法 。
On this basis, the DNA binding study of transition metal polypyridyl mixed-ligand complexes as DNA structural probe and antitumor reagent has some theoretical meaning and important application value.
在此基础上研究作为DNA结构探针和抗癌试剂的过渡金属多吡啶配合物与多聚核苷酸dna的相互作用，既有一定的理论意义，又有重要的应用价值。
This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain.
这类蛋白包含三个区域：一个C末端的配体识别域，一个N末端效应器结合域和一个位于中心的核结合寡聚化域。
This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain.
这类蛋白包含三个区域：一个C末端的配体识别域，一个N末端效应器结合域和一个位于中心的核结合寡聚化域。
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