Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2, 3).

依托泊苷能稳定酶催化性循环中的一种共价的拓扑异构酶ii裂解的DNA中间复合物，导致基因组不稳定性和细胞死亡(2,3)。

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Participants in the highest vs. the lowest quartile demonstrated a 4.3-fold greater risk of death, and the intermediate quartiles demonstrated intermediate risks, " the researchers write."

处于最高四分位的患者的死亡风险比最低四分位患者的死亡风险要高4.3倍，而中间两个四分位的患者的死亡风险则处于中间水平。

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Participants in the highest vs. the lowest quartile demonstrated a 4.3-fold greater risk of death, and the intermediate quartiles demonstrated intermediate risks, " the researchers write."

处于最高四分位的患者的死亡风险比最低四分位患者的死亡风险要高4.3倍，而中间两个四分位的患者的死亡风险则处于中间水平。

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