METHOD The cause of initial burst, the formulation parameters affecting initial release and approaches to reduce initial burst were all analyzed according to relevant literatures.
方法分析有关文献资料，对产生突释的原因、影响突释的因素以及减少突释的方法进行详细介绍。
Results: By adjusting LDME concentration and different polymer combinations, we achieved microspheres with high encapsulation efficiency, low initial burst and sustained release.
结果：通过调节药物浓度和不同高分子组合筛选出突释小，包封率高且缓慢释放的处方。
The pattern of drug release for 30 days in vitro fitted to zero order release plot, with an initial burst effect at the first day.
体外释放第一天呈突释效应，而后药物释放基本符合零级动力学过程。
The pattern of drug release for 30 days in vitro fitted to zero order release plot, with an initial burst effect at the first day.
体外释放第一天呈突释效应，而后药物释放基本符合零级动力学过程。
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