Hypermethylation of GNAT1 may not be oncogenic mechanisms of NPC.
GNAT 1基因的甲基化可能不是鼻咽癌的发病机制。
Global hypomethylation and regional hypermethylation are common mechanisms of aberrant expression of gene.
广泛的低甲基化和区域性高甲基化是基因异常表达的常见机制。
And the relationship between hypermethylation of SFRP2 gene and clinicopathological features were analyzed.
同时分析SFRP2基因超甲基化与临床病理特征的关系。
More important, though, if abuse in early life has caused hypermethylation, is whether there is any way to undo it.
更重要的是，如果早期的虐待真会导致过甲基化，是否有办法改善它。
Results:In ALL, the incidence of P16 hypermethylation or homozygous deletion is 80%, there is no abnormal in control.
结果：AL LP16基因高度甲基化或纯合缺失发生率为80 % ，而对照组无一例P16基因失活；
There is a hypermethylation sequential basis in the upstream region from the transcriptional start site of IRX1 gene.
IRX1基因转录起始点上游存在高甲基化结构基础。
There exist hypermethylation, abnormal transcription of FHIT gene and down-regulation expression of FHIT protein in liver cancer.
肝癌中存在FHIT基因高甲基化、转录异常、FHIT蛋白表达下降。
Objective:To investigate the function of promoter hypermethylation of secreted frizzled-related protein 2(SFRP2) gene in colorectal cancer.
目的：研究分泌型卷曲相关蛋白2（SFRP2）基因启动子超甲基化与大肠癌的关系。
In muscle tissues, the promoter hypermethylation status of adiponectin gene was detected, which was consistent with the expression of this gene.
脂联素基因在猪肌肉组织中以高度甲基化状态为主，这一结果与该基因在肌肉组织中表达量相吻合。
But the mechanism isn't perfect: "If you look at tumors, they tend to have hypomethylation overall, but hypermethylation in some genes," Sapienza says.
但这种机制尚不完善：“如果你审视肿瘤，它们往往具备整体低甲基化，但某些基因却超甲基化，”萨皮恩扎说。
The expression of p16 and DAPK protein were detected to analyse the relationship between the promoter hypermethylation and the loss of protein expression.
同时通过检测胃癌组织中基因的蛋白表达水平，了解基因高甲基化与其蛋白表达缺失之间的关系。
Recent studies showed that ARF gene may play a role in tumorigenesis; the ARF gene promoter hypermethylation may be the principal mechanism in the inactivation of this gene.
目前研究表明ARF基因在肿瘤发生过程中可有起一定的作用，ARF基因功能的失活可能主要通过该基因启动子高度甲基化。
This suggests that the hypermethylation in the suicide group was not just a general difference, says Dr Szyf, but rather a response to something specific, such as abuse suffered in childhood.
斯兹夫博士表示，这一差别意味着自杀组的基因过甲基化并非整体差异，而像是对一些特定情况的反应，比如说童年所遭受的虐待。
Methods: The hypermethylation was examined by methyl sensitive restrictive DNA endoenzyme analysis in 34 cases of angioreticuloma and the VHL gene mutations detected by PCR SSCP analysis.
方法：采用PCRSSCP法检测血管网织细胞瘤中VHL基因的突变率及甲基化，敏感限制性内切酶消化法检测血管网织细胞瘤中VHL基因的异常甲基化率。
AIM: To investigate the hypermethylation of the BLU and ARF promoter in nasal NK/T cell lymphoma from nasopharyngeal mucosa and its roles in tumor genesis and molecular pathological diagnosis.
目的：检测BLU与ARF基因启动子在鼻NK/T细胞淋巴瘤中的甲基化状态，探讨其在肿瘤发生中的作用与分子病理诊断中的应用价值。
AIM: To investigate the hypermethylation of the BLU and ARF promoter in nasal NK/T cell lymphoma from nasopharyngeal mucosa and its roles in tumor genesis and molecular pathological diagnosis.
目的：检测BLU与ARF基因启动子在鼻NK/T细胞淋巴瘤中的甲基化状态，探讨其在肿瘤发生中的作用与分子病理诊断中的应用价值。
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