Patients' DNA was sequenced directly or analyzed for specific mutations of HMGA1.
患者进行HMGA1的DNA直接测序或特定的突变分析。
Levels of messenger RNA and expression of HMGA1 and INSR proteins were also determined in patients with type 2 DM and control patients.
在2型糖尿病和对照患者也进行了信使RNA的水平和HMGA1与INSR的蛋白表达测定。
Objective: to construct and identify a lentiviral vector harboring RNAi sequence targeting the human high mobility group A1 (HMGA1) gene.
目的：构建和鉴定人高迁移率族蛋白组a 1 (HMGA1)基因rna干扰慢病毒表达载体。
Published March 2 in JAMA, this research built on the earlier report, investigating functional HMGA1 variants in patients with type 2 DM.
此研究发表在3月2日的JAMA杂志上，以较早的研究为基础，探讨了2型糖尿病患者的功能HMGA1变异。
The variant, designated IVS5-13insC, impairs function of the HMGA1 protein, a cofactor for gene activation that regulates insulin-receptor gene (INSR) expression.
这个变异称为IVS5-13insC，造成HMGA1蛋白的功能损伤，HMGA1蛋白是调节胰岛素受体基因（INSR）表达的辅助因子。
Objective: To explore the expression level of HMGA1 and COX-2 in breast cancer, analyze the relationship between HMGA1, COX-2 and the growth, differentiation invasive of breast cancer respectively.
目的：本文通过研究乳腺癌中HMGA1、COX - 2的表达情况，分析HMGA1、COX - 2与乳腺癌的生长、分化和侵袭性之间的关系。
Objective: To explore the expression level of HMGA1 and COX-2 in breast cancer, analyze the relationship between HMGA1, COX-2 and the growth, differentiation invasive of breast cancer respectively.
目的：本文通过研究乳腺癌中HMGA1、COX - 2的表达情况，分析HMGA1、COX - 2与乳腺癌的生长、分化和侵袭性之间的关系。
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