Unfolded proteins accumulate during ER stress and ER resident proteins GRP78 and GRP94 protect cells against ER dysfunction.
内质网受压时未折叠蛋白积累，内质网驻留蛋白GRP78和GRP94保护细胞免于内质网功能异常。
Objective To investigate the expression of the glucose regulated protein (GRP78, GRP94) in rats during focal cerebral ischemia.
目的研究大鼠局灶性脑缺血时糖调控蛋白(GRP78、GRP94)的表达。
Elevated protein expression of GRP78 was correlated positively with the content of MDA and HCY in plasma and the index of liver fibrosis (P<0.01).
表达增高的GRP78蛋白分别与血浆MDA和HCY水平以及肝纤维化指数呈显著正相关（P<0.01）。
Whether propofol in clinical dose affects the levels of GRP78 in normal liver cell is not clear, and further research is needed to resolve this question.
临床剂量的异丙酚对正常肝细胞内GRP78水平是否有影响尚不清楚，有待进一步研究。
Results: After LLLI preconditioning, increased VEGF and GRP78 expression, as well as the enhanced SOD activity and inhibited MDA production, was observed.
结果：LLLI预处理显著提高了梗死后心肌组织中vegf、GRP78的表达及SOD的活性，降低了MDA的含量。
Methods: icariin induced cultured rabbit vascular smooth muscle cell apoptosis, in situ hybridization in rabbit plaque GRP78 gene expression levels of the organization.
方法：淫羊藿甙诱导培养的兔血管平滑肌细胞凋亡，组织原位杂交观察凋亡基因GRP78在兔斑块组织中的表达水平。
Normal cells respond to ER stress by increasing transcription of genes encoding ER-resident molecular chaperones such as GRP94, GRP78 and PDI to facilitate protein folding.
细胞对这种应激的反应是增加一系列内质网分子伴侣如GRP94、GRP78和PDI等的表达。
Objective To evaluate the expression level of glucose regulating protein 78(GRP78) in the model of Parkinson's disease(PD)induced by 6-Hydroxydopamine(6-OHDA) in PC12 cells.
目的探讨神经毒素6-羟基多巴胺（6-OHDA）诱导PC12细胞的帕金森（PD）模型中GRP78的表达。
AIM: to explore the effect of glucose-regulated protein 78 (GRP78) expression on the biological behaviors of hepatocellular carcinoma cells with different metastatic potentials.
目的：研究葡萄糖调节蛋白78 (GRP78)在不同转移潜能肝癌细胞株内的表达及其对肝癌细胞生物学行为的影响。
Objective: To observe the nature of glucose-regulated protein 78 (GRP78) in atherosclerotic tissue and the possible mechanisms of icariin atherosclerosis prevention and treatment.
目的：观察葡萄糖调节蛋白基因78 (GRP78)在动脉粥样硬化组织中的表达，探讨淫羊藿甙防治动脉粥样硬化的可能机制。
AIM: To investigate the effect of high glucose on the expression of an endoplasmic reticulum stress marker glucose-regulated protein 78 (GRP78), and explore its underlying mechanism.
目的：观察高糖慢性处理对血管内皮细胞内质网应激标志蛋白葡萄糖调节蛋白78 (GRP78)表达的影响及其作用机制。
Conclusion: PC has a protective effect on cerebral IR injury, which may related to increased GRP78 and decreased CHOP expression, and to inhibition of the ERS-induced apoptosis pathway.
结论：PC对脑缺血再灌注损伤大鼠具有保护作用，其机制可能与其增加GRP78表达、拮抗chop表达、阻断内质网应激(ERS)启动的凋亡通路有关。
Conclusion Endoplasmic reticulum-self regulated system was started through the increased expressions of GRP78 and GRP94 after striatum ischemia in rats, so as to attenuated cerebral ischemic injury.
结论大鼠纹状体缺血后可能通过GRP78、GRP94表达升高启动内质网自稳调节系统；
Conclusion Endoplasmic reticulum-self regulated system was started through the increased expressions of GRP78 and GRP94 after striatum ischemia in rats, so as to attenuated cerebral ischemic injury.
结论大鼠纹状体缺血后可能通过GRP78、GRP94表达升高启动内质网自稳调节系统；
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