In the big environment that upsurges in tide of area economic integration, China still is in certain area economic integration besides, brought grim challenge to our country.

在区域经济一体化浪潮高涨的大环境中，中国还处于某些区域经济一体化之外，给我国带来了严峻的挑战。

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The epidemic situation of tuberculosis is more and more severe, especially drug-resistant mycobacterium tuberculosis make antituberculous chemical drug facing grim challenge.

结核病疫情日益严重，尤其是耐药结核分枝杆菌的出现，使抗结核化疗药物面临严峻的挑战。

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But before the footman could issue a challenge, the dark haired rider, his mouth set in a grim line, was already striding up the wide steps.

可是，男仆还能没来得及问话，来人就已大步跨上了宽阔的台阶。那男子一头黑发，严肃地抿着嘴巴。

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But before the footman could issue a challenge, the dark haired rider, his mouth set in a grim line, was already striding up the wide steps.

可是，男仆还能没来得及问话，来人就已大步跨上了宽阔的台阶。那男子一头黑发，严肃地抿着嘴巴。

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