Do they fit well with the newer drugs like GLP-1 analogues?
这类药物是否适合与像GLP - 1类似物这样的新型药物进行联合治疗？
CONCLUSIONS Artificial sweeteners synergize with glucose to enhance GLP-1 release in humans.
结论在人类，人工甜味剂和葡萄糖协调合作增加GLP - 1的分泌。
BYETTA is the first FDA-approved GLP-1 receptor agonist for the treatment of type 2 diabetes.
百泌达是FDA批准的治疗2型糖尿病的首个GLP - 1受体激动剂药物。
Patients with kidney failure should not be treated with GLP-1 because data from trials are not yet here.
由于目前尚没有试验数据，肾衰患者不应该使用GLP - 1治疗。
What makes it different is that it is based on the incretin hormone, GLP-1, which is secreted after a meal.
与众不同之处在于这类药物的作用机制是基于肠促胰岛素GLP-1的，GLP-1是在餐后分泌的。
With respect to renal impairment, overall we say that GLP-1 based therapy has the same indications as metformin.
肾功能损害方面，总体上讲，GLP - 1类药物与二甲双胍的适应症是相同的。
Thus, the function of GLP-1 is not limited to the islet cells, and it has regulatory actions on many other organs.
因此，GLP-1功能并不仅仅限于胰岛细胞，对于其他脏器同样有功能调节作用。
So lifestyle and GLP-1 interventions seem to actually be able to help patients keep their lifestyle to a better level.
因此生活方式干预和GLP-1治疗可能使患者的生活方式保持在一个更好的水平。
There are many challenges in developing an oral formulation of GLP-1, in particular obtaining adequate bioavailability.
开发口服型的GLP-1药物存在许多难题，尤其是需要有足够的生物利用度。
CONCLUSIONS -this study demonstrated that GLP-1 should be given continuously to obtain the most optimal glycemic control.
结论：本研究显示，GLP - 1应连续给药，以获得最优化的血糖控制。
International Diabetes: We have seen some research that suggests GLP-1 can improve endothelial function and heart function.
《国际糖尿病》：我们看到一些研究提示，GLP - 1可以改善内皮功能和心功能。
To investigate GLP-1’s role in taste, the team used a strain of mice that were genetically engineered to lack GLP-1 receptors.
为了弄清GLP-1在味觉中的作用，该研究小组使用了一组通过基因改造而缺失GLP-1受体的老鼠。
To investigate GLP-1's role in taste, the team used a strain of mice that were genetically engineered to lack GLP-1 receptors.
为了弄清glp - 1在味觉中的作用，该研究小组使用了一组通过基因改造而缺失glp - 1受体的老鼠。
This increase in GLP-1 secretion may be mediated via stimulation of sweet-taste receptors on L-cells by artificial sweetener.
GLP - 1分泌增加是通过人工甜味剂刺激L细胞上的甜味受体调节的。
CONCLUSIONS -monotherapy with GLP-1 and metformin have equal effects on plasma glucose and additive effects upon combination.
结论：GLP - 1和二甲双胍单药治疗对血糖效果相同，联合治疗会产生叠加效果。
One of DC treatment mechanisms is associated with its enhanced the islet cell proliferation by increasing the incretion of GLP-1.
其作用机制可能是与其通过促进GLP-1分泌进而促进胰岛细胞增殖有关。
We don't know who will benefit more from these drugs but I use GLP-1 therapy very often in many patients and they tolerate it fine.
我们不知道谁可以从此类药物中获益更多，但是我在许多患者中非常普遍的使用GLP-1治疗，而且他们耐受良好。
Dr Munger, though, found that both GLP-1 and the receptor molecule that picks it up and thus allows it to act are found in taste buds too.
而芒杰博士发现，在味蕾中也有GLP - 1和接收glp - 1并使其发生作用的受体的存在。
CONCLUSIONS Weight reduction with GLP-1 receptor agonists was associated with a shift toward a more favorable cardiovascular risk profile.
结论：GLP - 1受体激动剂治疗后的体重减轻与心血管危险因素谱向更有益的方向转变有关。
This review summarizes the function of GLP-1 on different organs including the stomach, heart, liver, and the central nervous system (CNS).
本篇综述总结了GLP - 1在不同脏器的功能作用，包括胃、心脏、肝和中枢神经系统。
In this study, we examined the effect of artificial sweeteners in a commercially available soft drink on glucose, insulin, and GLP-1 in humans.
本研究探讨软饮料中的人工甜味剂对人类葡萄糖、胰岛素和GLP - 1的作用。
Conclusion: GLP-1 can not only increase the insulin gene expression and insulin secretion, but also stimulate the proliferation of islet cells.
结论：GLP鄄1可促进大鼠胰岛细胞胰岛素基因的表达和蛋白的分泌，对大鼠胰岛细胞亦有明显的促增殖作用。
Furthermore, food intake was dramatically increased, but body weight gain was unchanged, showing that brain GLP-1 controlled energy expenditure.
此外，虽然增加食物的摄入，但治疗组体重却没有发生大的改变，说明脑glp - 1途径控制着能量的消耗。
International Diabetes: New treatments shown here at ADA has always paid close attention to exciting therapies and GLP-1 is one of those therapies.
《国际糖尿病》：ada年会公布的糖尿病新的治疗手段通常聚焦于令人激动的治疗方法，GLP - 1也是其中之一。
If we understood the physiology, and it is GLP-1 plus other things, then we should be able to reproduce it without having to perform surgery itself.
如果我们了解了生理学，且它是GLP-1加其他因素，那么我们应该不必进行手术本身就能够重现它。
The ability of GLP-1 in protecting endothelial function seems to depend on the level of glycemia, a phenomenon already described for insulin secretion.
GLP - 1在保护血管内皮功能的能力似乎取决于血糖水平，胰岛素的分泌已经显示出这个现象。
METHODS Natural products were collected to screen in the stable cell line of GLP-1 receptor, and the active component was identified in the PC12 cells.
方法建立稳定的GLP-1受体激动剂高通量筛选模型，从天然药物中筛选活性成分；在PC12细胞中验证GLP-1受体激动剂的功能及作用机制。
Drugs that block the degradation of natural endogenous GLP-1 enhance the function of GLP-1 and the net effects of that are to enhance glycemic control.
阻断内源性GLP - 1的降解的药物可增强GLP - 1的作用，它们的联合作用是强化血糖控制。
International Diabetes: the GLP-1 analogues have been widely available in the us market now. Can you tell use about the application timing of these drugs?
《国际糖尿病》：GLP - 1类似物现已在美国市场得到广泛应用。您可以给我们介绍一下这些药物的使用时间吗？
There are so many things we do not know, but a lot of encouraging results are being shown here at the ADA and we have much to learn with respect to GLP-1.
当然我们还有很多未知的东西，但是ADA给我们展示了很多令人振奋的研究结果，关于GLP-1我们还有很多要学习的东西。
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