Aim To research the relationship between the 3d structures and bio activities of gleevec.
目的研究小分子有机生物碱类药物格列维克的三维结构与生理活性之间的关系。
The estimated overall survival rate for patients receiving Gleevec was 88% when considering deaths from all causes.
在进行死因分析时，接受伊马替尼治疗的患者的总体生存率为88%。
Cumulative best responses to Gleevec treatment improved dramatically between the first and sixth years of treatment.
在治疗的第一年到第六年之间，伊马替尼治疗的累积最佳应答率显著提高。
Some patients have suffered relapses due to acquired point mutations in KIT, which prevents Gleevec from binding to the protein.
一些肿瘤复发的病人由于KIT发生了点突变，这阻止了Gleevec结合蛋白激酶。
Recent research shows that a new targeting therapeutic agent, SU11248, can prolong the survival time of the patients with GISTs who were resistant to Gleevec therapy.
最新研究表明新的靶向治疗药物SU11248对格列卫耐药的患者有延长生存期的作用。
The much touted anti-leukemia drug Gleevec here appears as the hero of modern, genetics-based cancer therapy, a “rationally designed” drug specifically directed against a known cancer gene.
格列卫（Gleevec）这种广为宣传的抗白血病药物在这里成了现代基因癌症治疗的英雄，是一种“理性设计”出来专门针对特定肿瘤基因的药物。
While Gleevec, a pill, transformed the treatment of a blood cancer called chronic myeloid leukemia, "our work suggests that most solid tumors are really nothing like CML," Vogelstein said.
而格列卫，来自于慢性髓细胞性白血病的药物。Vogelstein说：“我们的工作提示大多数实体肿瘤实际上不同于CML。”
There is already a targeted treatment for this disease. Gleevec, probably the most remarkable anti-cancer drug of the past decade, disables the protein encoded by another fused gene, BCR-ABL.
现在对这种病已有针对性疗法，Gleevec大体是过去十年中效果最显著的药物，它能使另一融合基因BCR-ABL的编码蛋白失去活性。
There is already a targeted treatment for this disease. Gleevec, probably the most remarkable anti-cancer drug of the past decade, disables the protein encoded by another fused gene, BCR-ABL.
现在对这种病已有针对性疗法，Gleevec大体是过去十年中效果最显著的药物，它能使另一融合基因BCR-ABL的编码蛋白失去活性。
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