Both clones included a DNA sequence that allow a fluorescent protein expressed in the cell to bind to cyclin D1 RNA the moment it is transcribed.
这两个克隆都包含有一段DNA序列,能在在细胞周期蛋白d1的RNA被转录的时候将荧光蛋白绑定到其上。
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle.
周期素d 1编码一种全酶的调节亚单位,该酶利用蛋白磷酸化灭活视网膜母细胞瘤蛋白,通过细胞周期G 1 - S期促进肿瘤进展恶化。
Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell cycle regulators in cancers.
细胞周期蛋白D1作为一个能促进有丝分裂和CDK4的变构激活剂,是癌症中较频繁变化的细胞周期调节子。
The entry of eukaryotic cells into mitosis is regulated by cdc2 kinase activation, a process controlled at several steps including cyclin binding and phosphorylation of cdc2 at Thr161 (1).
cdc2蛋白激酶的激活参与调节真核细胞进入有丝分裂,cdc2的激活受多个步骤的调控,包括周期蛋白的结合、cdc2苏氨酸161位的磷酸化(1)。
The entry of eukaryotic cells into mitosis is regulated by cdc2 kinase activation, a process controlled at several steps including cyclin binding and phosphorylation of cdc2 at Thr161 (1).
cdc2蛋白激酶的激活参与调节真核细胞进入有丝分裂,cdc2的激活受多个步骤的调控,包括周期蛋白的结合、cdc2苏氨酸161位的磷酸化(1)。
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