This antibody does not cross-react with Chk1 when phosphorylated at other sites.
该抗体不与其他位点磷酸化的Chk1蛋白发生交叉反应。
Other potential CHK1 functions include replication , chromatin remodelling and DNA repair.
另外CHK1其他潜在的功能包括复制、染色质改型和DNA修复。
Chk1 exerts its checkpoint mechanism on the cell cycle, in part, by regulating the cdc25 family of phosphatases.
Chk1发挥其细胞周期检验点调节机制部分经由调控磷酸酶家族的cdc25。
Chk1 has emerged as a drug target for cancer therapy as its inhibition leads to cell death in many cancer cell lines (9).
鉴于Chk1的抑制作用能够引起许多肿瘤细胞系的死亡，它已经成为肿瘤治疗中心的药物靶点(9)。
Research studies have implicated Chk1 as a drug target for cancer therapy as its inhibition leads to cell death in many cancer cell lines (9).
研究提示由于Chk1被抑制后会导致很多癌细胞死亡，Chk1可以作为癌症治疗的药物靶点(9)。
Conclusion: the results showed that AA12 and CHK1 proteins could interact with each other, this would be important for studying a new function of AA12 gene.
结论：AA12蛋白和CHK1蛋白之间存在相互作用，此结果为进一步研究新基因AA12的功能奠定了基础。
Activation of Chk1 involves phosphorylation at Ser317 and Ser345 and occurs in response to blocked DNA replication and certain forms of genotoxic stress (2).
Chk1的激活涉及317位和345位丝氨酸的磷酸化，其发生响应DNA复制阻滞和某些类型的基因毒性应激反应(2)。
An important part of the cellular response to DNA damage is checkpoint activation - checkpoint kinases CHK1 and CHK2 phosphorylate key proteins to elicit cell-cycle blocks.
细胞对DNA损伤作出应答的一个重要过程是检查点活化(检查点激酶CHK1和CHK2使关键蛋白磷酸化，从而阻止正常的细胞周期。)
An important part of the cellular response to DNA damage is checkpoint activation - checkpoint kinases CHK1 and CHK2 phosphorylate key proteins to elicit cell-cycle blocks.
细胞对DNA损伤作出应答的一个重要过程是检查点活化(检查点激酶CHK1和CHK2使关键蛋白磷酸化，从而阻止正常的细胞周期。)
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