Objective to explore the SV40-mediated immortalization, the related factors and their roles in cell immortalization.
目的探讨SV40如何介导细胞永生化，与细胞永生化现象相关的因素及它们的作用。
Telomere and telomerase are the focus of modern biological study. There are close relationships among telomere loss and cell ageing, activation of telomerase, cell senescence and immortalization.
端粒和端粒酶是现代生物学研究的热点，端粒的缺失与细胞的衰老，端粒酶的活性与细胞的老化及癌化均有密切的关系。
Telomere and telomerase are the focus of modern biological study. There are close relationships among telomere loss and cell ageing, activation of telomerase, cell senescence and immortalization.
端粒和端粒酶是现代生物学研究的热点，端粒的缺失与细胞的衰老，端粒酶的活性与细胞的老化及癌化均有密切的关系。
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