The amount of stored granzyme-A within single cells was always lower in HCV-specific CD8 cells, which were less efficient also in the release of lytic granules and in the production of TNF-alpha.
丙型肝炎病毒特异反应性CD8单细胞内粒酶A的储存量一直比较低，溶解的洋地黄毒素（lytic granules）的释放和TNF-α和产量也低。
That finding appears in the Journal of Leukocyte Biology. [Thomas A. Mace et al, Differentiation of CD8+ T cells into effector cells is enhanced by physiological range hyperthermia]
这一研究发表在《白细胞生物学杂志》[ThomasA. Maceetal,Differentiationof CD8+Tcellsinto effector cellsis enhanced by physiological range hyperthermia].
Hepatology Digest: you mentioned that there distinct differences of CD8 t cells in HCV patients. Can you please elaborate on this?
《国际肝病》：您曾提到，丙型肝炎患者之间的CD 8 +T细胞存在明显区别。您能详细解释一下吗？
However, research findings showed that a subset of CD8 + t cells was largely able to curtail viral replication in animal models and HIV infections.
然而，研究结果发现，在动物模型以及艾滋病感染中，CD 8 +T细胞亚类细胞仍然能在很大程度上抑制病毒的复制。
Nature magazine published online a research paper on Wednesday, claiming that virus-specific cells, CD8 + t, are able to control viral replication in both animal models and HIV infections.
星期三，《自然》杂志发表了一篇研究成果，指出CD 8 +T细胞亚类能抑制动物模型和艾滋病感染的病毒复制。
We demonstrate that the loss of this protein prevents the control of the infection and diminishes the function of the killer T-cells, specifically CD8 T-cells.
我们证明了这种蛋白质的缺失可以引起感染的失控，同时会减少杀伤t细胞的功能，尤其是CD 8 T细胞。
This study was performed to determine if activation of alloreactive CD4-independent, CD8+ T cells, by exogenous stimuli, can precipitate late loss of islet allografts.
该研究的目的在于明确是否同种异体反应性非CD4依赖的CD8+T细胞通过外生性刺激能够能够导致长期移植物的丢失。
ICOS is not expressed on the cell surface of circulating CD8 memory t cells but is rapidly upregulated during cell division within the allograft parenchyma.
在循环cd 8记忆T细胞的表明并没有ICOS的表达，但是其在移植物实质内细胞分化期间对其有正性调节作用。
ObjectiveTo explore the biological features of spleen CD8 + CD28 - t cells from spontaneous tolerance models of rats with orthotopic liver transplantation.
目的研究近交系大鼠原位肝移植自发免疫耐受模型中cd 8 +CD 2 8-T抑制细胞的生物学特点。
Objective to determine the expression level of CD69 on CD4 + and CD8 + t cells in peripheral blood from children with rheumatoid arthritis (ra), and investigate their role in the pathogenesis of ra.
目的分析小儿类风湿关节炎(RA)患者的外周血cd4 +、CD 8 +T细胞CD 69表达水平，探讨其在小儿关节炎症发生过程中的免疫病理作用。
The increase of CD3 + CD4 -cd8 - cells had correlated with mobilization effect of CD34 + cells into peripheral blood.
在各T淋巴细胞亚群中CD 3 + CD 4- CD 8 -细胞的增加与CD34 +细胞的动员效果间具有统计学意义的相关性。
Blood sample was gathered before and 5 days after intervention, testing hemogram, biochemical indexes, NK cells, CD3, CD4, CD8, temperature. Postoperative fever was observed in all the patients.
分别于介入术前及术后5天内采血，检测血象、生化指标、NK细胞、CD 3、CD 4、CD8及患者体温，观察患者术后有无发热现象等。
The authors next examined the inheritance of T-cell-fate-associated molecules by the first two daughter cells following asymmetrical cell division of CD8 + t cells.
其后，作者通过对CD 8 +T细胞不对称细胞分裂后的第一代两个子代细胞研究，证明了与T细胞命运相关的分子遗传性。
The multifactor linear regression analysis showed that the number of CD8 + cells was significantly negatively correlated to the disease course .
多元线性回归结果：抑郁症患者血中CD8+细胞数与病程呈非常显著负相关。
Conclusion: The activated state of CD8 + t cells are abnormal in asthmatic patients.
结论：哮喘病人CD 8 +T细胞活化状态明显异常。
CONCLUSION: No evidence suggests that the Utilin "s" has significant influence on human CD8 + t cells.
结论：应用乌体林斯注射液对人CD 8 +T细胞无显著影响。
Active CD4 + and CD8 + t cells have antitumor immunity and therapy functions.
活化cd 4 +和CD 8 +T细胞，同时产生抗肿瘤免疫和治疗作用。
Methods Expression of CD3, CD4 and CD8 antigen on peripheral blood t cells from 30 cases of hemodialysis and non-hemodialysis patients was evaluated by flow cytometry.
方法应用流式细胞仪法检测30例透析及未透析患者外周血t细胞表面的CD 3、及其亚群cd4及CD 8抗原表达。
The killing activity of NK cells and the proliferation rate of spleen cells were tested by MTT assay, and T cell subgroupCD4+ , CD8+ were tested by the indirect immune fluorescent assay.
用MTT方法对脾脏的NK杀伤细胞率和淋巴细胞的转化率进行测定，采用免疫荧光法对CD4+、CD8+细胞进行测定。
The NS3 protein with good immunogenicity appears to be a dominant target for dengue virus-specific CD4+ and CD8+ T cells, and most dengue virus NS3-specific T cells are serotype cross-reactive.
NS3具有良好的免疫原性，存在多个登革病毒特异性CD4+、CD8+T细胞表位，且多具有型间交叉免疫特性。
The results indicated that CD4 + and CD8 + cells were mainly distributed in the deep layer of cortex, and few of them in the medulla.
结果表明，CD 4阳性和CD 8阳性的细胞主要见于皮质深层，髓质中较少。
Conclusion: The conventional fractioned radiotherapy can activate cell mediated immunity of CD8+ T and NK cells, but inhibit the differentiation of T cells and NK cells signaling transduction pathway.
结论：放疗能部分激活CD8+T及NK细胞介导的杀伤免疫，同时抑制T细胞和NK细胞的分化及其信号传导通路。
Now Connors and his research team found that more CD8 + t cells through the venom will be transported to the infected cells, which control the onset of AIDS.
现在康诺斯和他的研究团队发现有较多CD 8 +T细胞的人通过将毒液输送到受感染的细胞，从而控制艾滋病的发作。
They found that CD8 + t cells in infected people has been very rapid growth, which more than the average person to control AIDS.
他们发现CD 8 +T细胞在受感染的人身上生长得非常迅速，从而比一般人更能控制艾滋病。
The frequency and functionality of HBVspecific CD8 + t cells in the liver and spleen were determined by dimer staining and intracellular cytokine staining after stimulation with HBV peptides.
通过二聚体染色和HBV肽刺激后的细胞内细胞因子染色测定肝和脾中HBV特异性CD 8 +T细胞的频率和功能。
Prof Robert Thimme: I think we have to focus on the inhibitory receptors, in order to ensure that the CD8 t cells are functioning again.
Thimme教授：我认为，我们必须将重点放在抑制性受体上，以确保CD 8 +T细胞能再次应答。
CD28+T cells, including CD4+CD28+T cells and CD8+CD28+T cells increased significantly in complete remission patients After the efficient treatment with corticosteroid(P<0.01).
激素有效组尿蛋白转阴后CD28分子水平明显上升，且CD4+CD28+T细胞和CD8+CD28+T细胞均较治疗前明显上升，差异有统计学意义（P<0.01）；
The frequencies of HBV-specific CD8 + t cells were the highest in the liver, followed by that in the spleen and peripheral blood.
HBV特异性CD 8 +T细胞的表达频率在肝脏中最高，其次是在脾脏和外周血中。
The treated patients with persistent positive RPR within two years had elevated levels of CD3, CD4 and CD8 lymphocytes (P<0.05), but NK cells appeared to be lowered (P<0.05);
经过驱梅治疗但RPR持续阳性两年内的患者CD3、CD4及CD8淋巴细胞数显著高于对照组（P<0.05），NK淋巴细胞显著低于对照组（P<0.05）；
The CD3 and CD8 positive cells in the area surrounding the infarction core were round and had two forms:small and big cells;
位于坏死区周围的CD3阳性和CD8阳性细胞主要为圆形，有大细胞和小细胞两种形态；
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