Bisphosphonate have bone? Seeking affinity, some of them are used as drugs for osteoporosis.
双膦酸盐有趋骨性并有抗骨质疏松症活性。
However, it causes serious complications named as bisphosphonate-related osteonecrosis of jaw.
此药物可能引起严重并发症——颌骨坏死。
Conclusions Osteoclast-mediated bone resorption was inhibited by the bisphosphonate administration.
结论双膦酸盐对破骨细胞性骨吸收有明显的抑制作用。
Bisphosphonate medicines are a common treatment that can be used to slow the effects of the condition.
二膦酸盐药物，是一种常见的治疗可以用来缓慢的影响条件。
But I think it could influence the decision making of women who are deciding whether to take a bisphosphonate or not.
但是我认为它能影响女性是否服用双磷酸盐类的决定。
Results By 3 weeks when bisphosphonate started to be administered, woven bones formed in the periphery of the BMP pellets.
结果：BMP诱导骨3周时（即双膦酸盐未投药前），在BMP植入体周边形成编织骨，大量破骨细胞出现在新生骨组织表面。
Objective To determine the effects of bisphosphonate (YM175) on the quality of bone morphogenetic protein (BMP) -induced bone.
目的：研究双膦酸盐对骨形成蛋白(BMP)诱导骨的作用。
The duration of treatment and length of the holiday are based on fracture risk and pharmacokinetics of the bisphosphonate used.
双磷酸盐的使用周期是以双磷酸盐的药理学作用，以及其骨折风险作为基础的。
Although no cause and effect relationship between bisphosphonate therapy and osteonecrosis has been established, it is suspected.
尽管使用双磷酸盐和骨坏死之间的因果联系还没有建立，人们怀疑它们之间有因果联系。
Dental treatments and procedures that require bone healing should be completed before initiating intravenous bisphosphonate therapy.
在开始静脉注射双磷酸盐之前，应该完成需要骨头痊愈的牙科治疗程序。
Clodronate is an alternative bisphosphonate approved worldwide, except in the United States, for oral or intravenous administration.
氯磷酸二钠是一种替代双磷酸盐批准全球，除了在美国口服或静脉注射。
There was no significant increase in risk associated with bisphosphonate use, but the study was underpowered for definitive conclusions.
在二膦酸盐的应用过程中，骨折的风险没有明显的增加，但是这些研究还不能得出明确的结论。
Importance of calcium co-medication in bisphosphonate therapy of osteoporosis: an approach to improving correct intake and drug adherence.
钙的重要性的共同药物双膦酸盐治疗骨质疏松症：一个正确的方法来提高摄入量和药物遵守。
So drug companies came up with a way to stop osteoclasts from removing the old tissue, which also artificially increases your bone density: bisphosphonate drugs.
因此，制药公司想出了一个办法，阻止了破骨细胞清除旧骨组织，如此人工化地添加了你的骨骼密度：这就是所谓的“双磷酸盐”药物。
Conclusion: in groups of patients, short-term changes in markers of bone turnover appear to be predictors of longer term BMD response and nonresponse to bisphosphonate therapy.
结论：短期内骨转化标志物的变化可以预测患者骨密度对双磷酸盐治疗的远期反应。
MAIN OUTCOME MEASURES: the primary analysis examined the association between hospitalization for a subtrochanteric or femoral shaft fracture and duration of bisphosphonate exposure.
主要转归指标：主要分析调查了因股骨转子下骨折或股骨干骨折住院与双膦酸盐暴露时间之间的关联性。
Purpose: Limited data are available on the efficacy of oral bisphosphonate therapy in breast cancer survivors. Our goal was to examine prevention of breast cancer-related bone loss in this cohort.
目的：因为目前关于乳腺癌患者预防性应用双膦酸盐疗效的研究数据比较少，我们此次试验的目的就是研究乳腺癌相关性骨丢失的预防。
For patients currently receiving bisphosphonates who require dental procedures, there is no current evidence to suggest that interrupting bisphosphonate therapy will prevent or lower the risk of ONJ.
正在接受双磷酸盐治疗的患者如果需要进行牙科治疗，目前没有证据显示中断双磷酸盐治疗可以防止或降低发生ONJ的风险。
For patients currently receiving bisphosphonates who require dental procedures, there is no current evidence to suggest that interrupting bisphosphonate therapy will prevent or lower the risk of ONJ.
正在接受双磷酸盐治疗的患者如果需要进行牙科治疗，目前没有证据显示中断双磷酸盐治疗可以防止或降低发生ONJ的风险。
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