• This specificity of the binding pocket is half polar and half neutral according to the surface charge property.

    依照表面电荷性质这个结合特异性极性中性

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  • The mutations, including in-frame deletions at exon 19 and substitutions at exon 18 or exon 21, cluster around ATP-binding pocket of TK domain.

    这些突变均发生在酪氨酸激酶域ATP结合域附近,突变为19号外显子上的缺失突变,1821号外显子上的替代突变。

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  • Moreover, the substituents on the bicyclic chromophore can also produce strong van der Waals and hydrophobic interactions with the residues located at the exterior part of the binding pocket.

    同时抑制剂双环取代基团活性口袋外部部分基形成一定范德华和相互作用。

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  • The conserved surface patch and the deep pocket are responsible for binding to PP2A and ATP, respectively.

    这种保守的表面补丁口袋负责分别与PP2AATP结合。

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  • The conserved surface patch and the deep pocket are responsible for binding to PP2A and ATP, respectively.

    这种保守的表面补丁口袋负责分别与PP2AATP结合。

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