The majority of patients with mild HPA and mild PKU who had the R241C allele responded to BH4 administration.
许多患轻度PKU和轻度HPA且有R241C基因位点的病人，都对BH4治疗有反应。
Patients with BH4 deficiency should be treated early with BH4 and a combination of neurotransmitter precursors.
BH4缺乏症者应尽早接受BH4及神经递质前质联合治疗。
All cases were diagnosed as BH4 deficiency by analysis of urinary pterins profile, BH4 loading test, and determination of dihydropteridine reductase in RBC.
所有患者均经尿蝶呤谱分析、BH4口服负荷试验及红细胞二氢蝶呤还原酶测定，确诊为BH4缺乏症。
The team of international researchers, based at Massachusetts General Hospital (MGH), Boston, say BH4 levels might also determine a person's vulnerability to chronic pain.
以哈佛大学附属麻省总医院（MGH）为基础的国际研究团队说四氢生物蝶呤（BH4 ）的水平也决定人忍受慢性疼痛得脆弱性。
Tests in rat models found that the BH4-synthesizing enzymes were activated in injured sensory neurons and that substances known to inhibit those enzymes reduced pain, acting as analgesics.
大鼠模型的研究发现BH4合成酶在损伤的神经元中被激活，而那些抑制这些酶活性的物质象镇痛药一样能够减少疼痛。
As a result of the animal studies, the researchers hypothesized that particular variations of human genes involved in the regulation of BH4 might be associated with different responses to pain.
根据动物试验得到的结果，研究者推论人类涉及BH 4调控的基因特殊变异与对疼痛的不同反应相关。
As a result of the animal studies, the researchers hypothesized that particular variations of human genes involved in the regulation of BH4 might be associated with different responses to pain.
根据动物试验得到的结果，研究者推论人类涉及BH 4调控的基因特殊变异与对疼痛的不同反应相关。
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