Objective To study the percutaneous permeation of menthol and azone for acyclovir gel.
目的研究薄荷醇和氮酮对阿昔洛韦凝胶皮肤渗透性的影响。
AIM: To investigate the effects of penetration enhancer 1-menthol and azone on percutaneous absorption of bifonazole in vitro.
目的：研究透皮促进剂氮酮和薄荷醇对外用抗真菌药联苯苄唑体外经皮渗透性影响。
Methods Rats skin in vitro was applied, studying the effect of different concentrations of azone in Cytarabine ointment on drug permeation.
方法采用小鼠离体皮肤作为渗透屏障，研究不同浓度氮酮对阿糖胞苷促渗作用的影响。
Objective To investigate the effect of two kinds of permeation enhancers, azone and clove bud oil, on transdermal permeation of Shuxiong cataplasm.
目的探讨氮酮、丁香油两种渗透促进剂对舒胸巴布剂透皮渗透的影响。
Synthesis of azone was carried out from azacycloheptan-2-one and 1-bromododecane using KOH as condensation agent and PEG-400 as phase transfer catalytic agent.
以氮杂环庚—2—酮和1—溴十二烷为原料合成氮酮，用氢氧化钾为反应缩合剂，PEG—400为相转移催化剂。
OBJECTIVE: to study the enhancing effects of azone at different concentrations on percutaneous permeation of compound tinidazole gel and to find out the best concentration.
目的：研究不同浓度的氮酮对复方替硝唑凝胶透皮吸收的作用，并筛选出最佳浓度。
Although 2% menthol crystal or 5% eucalyptus oil was effective as a natural penetration enhancer when used alone, the average penetration rate reached only half of that of 8% azone.
天然类促进剂单用时，2%薄荷醇和5%桉叶油促透效果较佳，但平均渗透速率约为8%氮酮的一半。
To study the effects of different concentration of penetration enhancer including propylene glycol, azone and oleic acid on the permeation of shikonin through excised rat abdomen skin.
研究不同浓度的丙二醇、氮酮和油酸对紫草素透过大鼠腹部皮肤的影响。
RESULTS&CONCLUSION:Azone at different concentrations could promote the permeability of3ingredients of compound tinidazole gel, and2%azone had the most obvious permeation-enhancing effect.
结果与结论：不同浓度的氮酮对复方替硝唑凝胶中3组分的渗透性均有促进作用，其中浓度为2 %的氮酮透皮促渗作用最显著。
The best ratio of adding Azone in Gel is 2%.
优选氮酮的最佳加入浓度为2％。
Objective To study the effect of different solvent systems on in vitro penetration rate of aciclovir gel enhanced by Azone for optimizing the formulation of aciclovir gel.
目的研究阿昔洛韦凝胶中的不同溶剂系统对主药体外透皮速率及对氮酮促渗作用的影响，为优化阿昔洛韦凝胶处方提供实验依据。
Objective To study the effect of different solvent systems on in vitro penetration rate of aciclovir gel enhanced by Azone for optimizing the formulation of aciclovir gel.
目的研究阿昔洛韦凝胶中的不同溶剂系统对主药体外透皮速率及对氮酮促渗作用的影响，为优化阿昔洛韦凝胶处方提供实验依据。
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