Objective: To optimize the preparation procedure of aripiprazole.
目的：优化阿立哌唑的制备工艺。
Results Aripiprazole was confirmed by elemental analysis and IR. The total yield was 81%.
结果阿立哌唑总收率为81%，经元素分析、红外光谱确证化学结构正确。
The incidence rate of adverse effect is 42.4% in Ziprasidone group and that is 57.6% in Aripiprazole group.
齐拉西酮组总不良反应发生率为42.4%，阿立哌唑组总不良反应发生率为57.6%。
OBJECTIVE: To evaluate the efficacy and safety of aripiprazole in the treatment of tic disorder when tiapride is used as a control.
目的：比较阿立哌唑与泰必利治疗儿童抽动障碍的疗效和安全性。
Results: 1 After treatment, the BMI, WHR levels increased significantly in risperidone, quetiapine and aripiprazole groups (P0. 05).
结果：1治疗后，三组患者的BMI,WHR水平均升高，与治疗前比较差异有统计学意义(P 0.05)。
The invention relates to the field of medicine synthesis and discloses a novel preparation method and an intermediate for aripiprazole.
本发明涉及药物合成领域，公开了阿立哌唑的制备新方法及其中间体。
Results: There were significant differences in the blood prolactin and body index after treatment between aripiprazole and risperidone groups.
结果：阿立派唑与利培酮对女性患者血清催乳素、体型指数的影响有显著差异。
Conclusion: the combination of aripiprazole with fluoxetine is better than aripiprazole alone in the treatment of treatment resistant depression.
结论：阿立哌唑合并氟西汀治疗难治性抑郁症的疗效优于单用氟西汀，且耐受性好。
Objective: To observe the efficacy and safety of small doses of aripiprazole in the treatment of attention deficit and hyperactive disorder (ADHD).
目的：观察小剂量阿立哌唑治疗注意缺陷与多动障碍(ADHD)的临床疗效及不良反应。
The incidences of extra-pyramidal symptoms and endocrine change in Risperidone group were obviously higher than those in Aripiprazole group(P<0.05).
利培酮组锥体外系不良反应和内分泌改变的发生均明显高于阿立呱唑组（P均<0.05）。
Method:Forty-eight children and adolescents diagnosed with autism or mental retardation accompanying with behavior disorder were treated by aripiprazole.
目的：观察阿立哌唑治疗儿童孤独症和精神发育迟滞的多动及冲动等行为障碍的疗效及不良反应。
CONCLUSION Combined a low dose aripiprazole to long term treatment for schizophrenia patient antipsychotics-induced hyperprolactinemia is effective and safe.
结论：合并小剂量阿立哌唑治疗抗精神病药所致高催乳素血症的长期效应好，安全性高。
Aripiprazole in overall yield of 68% was synthesized from 2, 3-dichloroaniline by a three-step nucleophilic substitution reaction in yield of 83%, 91% and 90%, respectively.
以2,3 -二氯苯胺为原料，经3步亲核取代反应合成了阿立哌唑。3步反应的收率分别为83%，91%和90%；总收率68%。
Conclusion Both of Aripiprazole and Risperidone show good effect and less side effects on Schizophrenia, so we can choose anyone according to curative effect and reaction degree.
结论阿立哌唑与利培酮治疗精神分裂症疗效均好、副反应少，可根据疗效和反应程度不同选择使用。
Conclusion Both of Aripiprazole and Risperidone show good effect and less side effects on Schizophrenia, so we can choose anyone according to curative effect and reaction degree.
结论阿立哌唑与利培酮治疗精神分裂症疗效均好、副反应少，可根据疗效和反应程度不同选择使用。
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