Post-Marketing Surveillance and Pharmacovigilance of antimalarials.
对抗疟药物的上市后监测和药物警戒。
AIM: To develop an in vitro assay incorporated with metabolism for screening antimalarials.
目的：建立一种结合肝微粒体代谢的抗疟药体外筛选方法。
Does that mean that ACTs – the most effective antimalarials to date – will soon be rendered useless?
这是否意味着迄今为止最有效的抗疟疗法——以青蒿素为基础的联合疗法将很快丧失效用？
This failure is due to resistance to artemisinin, our best and last class of effective antimalarials.
这是因为对最佳，也是最后一类有效抗疟药——青蒿素，产生耐药性所导致的失败。
While a major effort is under way to develop new classes of antimalarials, no replacement products are on the immediate horizon.
虽然正在加大努力研制新型抗疟药物，但没有近期可见的替代制品。
For example, simple colorimetric assays developed for artemisinins have been used successfully to identify fake artesunate antimalarials.
例如，已运用为青蒿素开发的简单比色测定法成功鉴定了假青蒿琥酯抗疟药物。
Two of these come from the generic industry while the remaining three are produced by brand name companies. All WHO recommended antimalarials were also added.
其中两种来自通用药物生产企业，而其余三种由名牌公司生产。
Unlike previous antimalarials that have been rendered useless in many regions due to drug resistance, Artemisinin Combination Therapies (ACTs) are now recommended.
与在许多地区由于耐药性而无效的以前各种抗疟药不同，目前推荐使用以菁蒿素为基础的联合治疗药物。
Their use can result in treatment failure (and contribute to increased resistance in the case of antimalarials that contain insufficient active ingredient) or even death.
使用假药可能导致治疗失败（和因有效成分含量不足从而增强抗疟药物的抗药性），甚至造成死亡。
With resistance to once effective antimalarials like chloroquine now widespread in Asia, Africa and South America , the prognosis could not seem more grim. "We're in a desperate situation."
随着对像氯喹这样在亚洲、非洲和南美洲广泛应用并曾经有效的抗疟疾药的抗药性的出现，疟疾的治疗状况可能更令人堪忧，“我们已处在绝望的境地。”
With resistance to once effective antimalarials like chloroquine now widespread in Asia, Africa and South America , the prognosis could not seem more grim. "We're in a desperate situation."
随着对像氯喹这样在亚洲、非洲和南美洲广泛应用并曾经有效的抗疟疾药的抗药性的出现，疟疾的治疗状况可能更令人堪忧，“我们已处在绝望的境地。”
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