ABSTRACT Ingenious modification of structure of natural antibiotics could improve their properties, which is one of ways to search for new drugs.
天然抗生素结构的适当修饰可改善其性能，是探索开发新的有效途径之一。
Mechanisms of antibiotics resistance includes: (1) target site modification; (2) production of inactive enzymes; (3) decrease of drugs penetrance; (4) expression of efflux pumps.
抗菌药物耐药机制包括：(1)靶位修饰；(2)产灭活酶；(3)药物渗透力下降；(4)外排泵表达。
Ingenious modification of structure of natural antibiotics could improve their properties, which is one of ways to search for new drugs.
天然抗生素结构的适当修饰可改善其性能，是探索开发新药的有效途径之一。
Ingenious modification of structure of natural antibiotics could improve their properties, which is one of ways to search for new drugs.
天然抗生素结构的适当修饰可改善其性能，是探索开发新药的有效途径之一。
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