We demonstrated a direct role for histone modifications in alternative splicing.
我们证明了组蛋白修饰在选择性剪接中一个直接的作用。
CD72 is a B cell specific receptor that exists in multiple alternative splicing forms.
CD 72是一个重要的B细胞特异性受体，它以多种选择性剪切形式存在。
Moreover, the rate of transcription elongation has been linked to alternative splicing.
此外，转录延伸速率也与可变剪接相关。
Alternative splicing plays an important role in processes such as development, differentiation and cancer.
可变剪接在发育、分化和癌症等过程中发挥着非常重要的作用。
Studying alternative splicing mechanism is of great significance to understanding eukaryote gene regulation.
研究基因的可变剪接对理解真核生物基因调控具有十分重要的意义。
The unique alternative splicing makes ZNF191, ZNF396 and ZNF397 genes encode two distinct proteins respectively.
这种独特的变异剪接形式使ZNF191、ZNF396和ZNF397基因分别产生两种不同的蛋白质。
Spliced alignment is a sequence alignment method which considers the different alternative splicing forms during alignment.
剪接比对指的是在比对过程中考虑不同选择性剪接方式的序列比对方法。
Alternative splicing is often regulated in tissue-and developmental stage-specific manner, or in response to extracellular stimuli.
可变剪接具有高度的组织与发育阶段特异性，并受到外界信号的控制。
A heuristic algorithm for multiple alignment was developed to more effectively study alternative splicing patterns of eukaryotic genes.
为对真核基因的选择性剪接形式进行准确、快速、有效的研究，提出了一种启发式多序列比对算法。
Spliceosome assembly occurs co-transcriptionally, raising the possibility that DNA structure may directly influence alternative splicing.
剪接体组装与转录同步进行，提示DNA结构可能直接影响可变剪接。
Alternative splicing didn't help either: it could be argued that it represents a case of RNA making itself, then making a bunch of different proteins.
选择性拼接也不肯帮忙：它可以被看作另外一种例外——RNA还能自我复制，然后制造出一揽子形形色色的蛋白质。
Alternative splicing is generally believed to occur more than 50% of actively transcribed human genes and thus is highly relevant to disease and therapy.
人类的基因中，超过50%的转录产物进行选择性剪接，而这机制和疾病发生、治疗方法有高度的相关性。
In recent years, more and more researches showed that alternative splicing was highly relevant to cancer, and many cancer genes were regulated by alternative splicing.
近年来，越来越多的研究表明可变剪接与癌症有着密切的关系，许多癌症相关基因受可变剪接调控。
The researchers discovered this transition in cancer cells when they observed an error in "alternative splicing, " a key element of the genetic copying program inside cells.
科学家们通过在观察选择剪切时发现的一个错误，在癌细胞中发现了这种转变。
Until 20 years ago, scientists believed that a single gene made a single protein. With the discovery of alternative splicing, it became clear that one gene can produce multiple proteins.
20年前，科学家们都认为一个基因对应一个蛋白，当发现选择性剪切后就知道了一个基因可以生成多种不同的蛋白。
Until 20 years ago, scientists believed that a single gene made a single protein. With the discovery of alternative splicing, it became clear that one gene can produce multiple proteins.
20年前，科学家们都认为一个基因对应一个蛋白，当发现选择性剪切后就知道了一个基因可以生成多种不同的蛋白。
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