AKT inhibitors have been used in trials on cancer patients before but with limited success.
AKT抑制剂以前在癌症患者身上做过实验，但效果有限。
"This underscores the importance of discovering the origin of active Akt in glioblastomas," he said.
“这突出了发现胶质母细胞瘤中活性Akt蛋白的重要性，”他说。
Methods the expression of AKT, PTEN had be detected for the specimens of 48 osteosarcoma and 15 exostosis with immunohistochemistry SABC method.
方法采用免疫组织化学SABC法检测48例骨肉瘤、15例骨软骨瘤标本中akt、PTEN表达的阳性细胞。
Decreased PTEN protein and increased AKT protein might be a marker for the early detection of the occurrence of colorectal cancer in patients with UC.
PTEN蛋白表达的明显降低和AKT蛋白表达的明显增强有可能成为早期监测uc癌变的一个辅助指标。
This loss of phosphorylation is due to less activity in one enzyme, AKT, that facilitates the process, and excess activity of phosphatases, that reverse it.
这一损失的磷酸化，是由于少活性酶之一，AKT的，便利的过程中，过剩的活性磷酸，扭转这一趋势。
This data complements Drosophila genetics studies suggesting the possible involvement of the tuberin-hamartin complex in the PI3K/Akt mediated insulin pathway (8-10).
这些数据和果蝇（Drosophila）遗传学研究表明tuberin-hamartin 复合物可能在PI3K/AKT介导的胰岛素通路中取作用（8-10）。
Conclusion: ROS, PTEN and p-AKT are involved in the signaling pathway of glucose-stimulated insulin secretion in INS-1cell, as signaling molecules in insulin secretion.
结论：ROS、PTEN及P -AKT参与了葡萄糖刺激INS - 1细胞分泌胰岛素的信号通路，成为介导胰岛素分泌的信号分子。
Zakrzewicz will present data from studies showing that the transcription factor Foxo-1, first described in 1999, can be inactivated by shear stress via Akt-mediated phosphorylation.
Zakrzewicz在他的综述中所提供的研究数据表明Foxo - 1转录因子(1999年首次被描述)可以被剪切应力通过Akt所介导的磷酸化作用所灭活。
The AKT-mediated signal pathway has been shown to be impaired in patients with schizophrenia, and antipsychotic medication may induce AKT activation, to compensate for the impairment.
AKT介导的信号通路在精神分裂症患者中发现有受损，而抗精神分裂症药物可以导致AKT激活，补偿这种受损。
Aim: To investigate the expression of phosphorylated AKT (p-AKT) and proliferating cell nuclear antigen (PCNA) in human non-small cell lung cancer (NSCLC) tissue and their correlations.
目的探讨非小细胞肺癌(NSCLC)组织中磷酸化akt (p -AKT)和细胞增殖核抗原(pcna)的表达。
A recent clinical trial using an EGFR inhibitor found that patients whose tumors expressed high levels of phosphorylated - or chemically altered - Akt did not respond to treatment, Kwatra said.
最近一项使用表皮生长因子受体抑制剂的临床试验发现，患者的肿瘤细胞表达磷酸化或化学转化水平很高-Akt对这种疗法没有反应“Kwatra博士说。”
We propose that the elevated levels of phosphorylated Akt may come from active forms of NK1R, and it's possible that a better response might be obtained by simultaneously blocking EGFR and NK1R.
我们预测高浓度的磷酸化akt蛋白可能来自活化的NK1R受体，所以同时抑制EGFR和NK1R受体可能获得更好的效果。
We propose that the elevated levels of phosphorylated Akt may come from active forms of NK1R, and it's possible that a better response might be obtained by simultaneously blocking EGFR and NK1R.
我们预测高浓度的磷酸化akt蛋白可能来自活化的NK1R受体，所以同时抑制EGFR和NK1R受体可能获得更好的效果。
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