Objective:To synthesize a key intermediate of anti-hypertension drug Losartan, 2-butyl-4-chloro-5-formylimidazole(1).
目的：合成抗高血压药氯沙坦的关键中间体2-正丁基-4-氯-5-甲酰基咪唑。
4-chloro-2-trifluoromethyl aniline was synthesized from 2-trifluoromethyl aniline, using hydrochloric acid-hydrogen peroxide as the chlorination agent and cupric chloride as the catalyst.
以邻三氟甲基苯胺为起始原料，二水氯化铜为催化剂，盐酸-双氧水为氯化剂，合成4 -氯- 2 -三氟甲基苯胺。
A synthetic method of direct cyclization was researched that 2-chloro-2-chloromethyl-4-cyanobutyraldehyde was reacted with phosphorus oxychloride to get 2-chloro-5-chloromethylpyridine.
研究了一种直接环合的方法，用2-氯-2氯甲基- 4-氰基丁醛与三氯氧磷反应来制备2-氯-5-氯甲基吡啶。
The reaction mixture then undergo esterification and rearrangement reaction to prepare 1-chloro-2-methyl-4-(acetyloxy)-2-butene, which is a important intermediate of vitamin A.
反应混合物可以进一步酯化重排制备维生素A的中间体1-氯-2-甲基-4-乙酰氧基-2-丁烯。
Several synthesis methods for the preparation of 2-chloro-4-aminopyridine were summarized in the article. The applications of 2-chloro-4-aminopyridine in heterocyclic synthesis were introduced.
本文综述了2-氯-4-氨基吡啶的制备方法，并介绍了2-氯-4-氨基吡啶在调吡脲等杂环化合物合成方面的应用。
The synthesis of 5-chloro-2-methyl-4-isothiazoline-3-ketone with multisodium sulfide, methyl acrylate, methyl amine, had been studied. The product had good ability of killing the mold and bacteria.
以多硫化钠、丙烯酸甲酯、甲胺等为原料合成杀菌剂5 -氯- 2 -甲基- 4 -异噻唑啉- 3-酮，具有很好的杀灭细菌、霉菌的能力。
The synthesis of 5-chloro-2-methyl-4-isothiazoline-3-ketone with multisodium sulfide, methyl acrylate, methyl amine, had been studied. The product had good ability of killing the mold and bacteria.
以多硫化钠、丙烯酸甲酯、甲胺等为原料合成杀菌剂5 -氯- 2 -甲基- 4 -异噻唑啉- 3-酮，具有很好的杀灭细菌、霉菌的能力。
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