而惰性骨钙蛋白的积累反过来会推动破骨细胞发生作用，使他们逐渐的消解骨骼。
Accumulation of inactive osteocalcin instead nudges osteoclasts into action, causing them to gobble up bone.
卡尔·桑迪将这一过程称为一种“前馈”循环，在此过程中胰岛素刺激骨钙蛋白的生成，而骨钙蛋白反过来可以刺激更多胰岛素的产生。
Karsenty calls this process a "feed-forward" loop, where insulin stimulates the production of osteocalcin, which in turn stimulates more insulin production.
目的通过检测特发性身材矮小(ISS)儿童血清骨碱性磷酸酶(BAP)及骨钙蛋白(OC)水平，探讨其成骨细胞的功能状况。
Objective To detect serum bone specific alkaline phosphatase (BAP) and osteocalcin (oc) in children with idiopathic short stature (ISS), and explore the status of osteoblast.
卡尔·桑迪的研究小组进一步发现骨吸收过程创造出了一种酸性环境从而将骨钙蛋白转变为一种“积极”体，这种“积极”体能够脱离骨骼而进入血液循环。
Karsenty's team further found that the bone resorption process creates an acidic environment that converts osteocalcin into an "active" form, which can escape bone and enter circulation.
卡尔·桑迪的研究小组进一步发现骨吸收过程创造出了一种酸性环境从而将骨钙蛋白转变为一种“积极”体，这种“积极”体能够脱离骨骼而进入血液循环。
Karsenty's team further found that the bone resorption process creates an acidic environment that converts osteocalcin into an "active" form, which can escape bone and enter circulation.
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