骨桥蛋白（OPN）是一种细胞外基质蛋白。
以往的一些研究确定了骨桥蛋白与肝脏的一些关系。
Previous studies have established a relation between osteopontin and the liver.
另一项研究发现缺少骨桥蛋白基因的小鼠不易出现肝损伤。
Another showed that mice lacking the osteopontin gene developed less hepatic injury.
本文就骨桥蛋白在骨质疏松症的发病中所起作用作一综述。
This article reviews the effect of osteopontin on onset of osteoporosis.
目的：探讨骨桥蛋白在硬皮病患者局部皮损表达和分布情况。
Objective: To explore the expression and distribution of osteopontin in local lesions of scleroderma patients.
骨桥蛋白在骨肉瘤远处转移过程中的作用有待进一步研究。
The role of OPN playing in the process of distant metastasis of osteosarcoma is required a further study.
目的探讨骨桥蛋白(OPN)的表达和调控与尿石症的关系。
Objective To investigate the relationship between the expression and regulation of osteopontin (OPN) and urolithiasis.
目的：评价骨桥蛋白作为肿瘤血清标记物在胰腺癌诊断中的作用。
Objective: To evaluate the effect of osteopontin as serum tumor marker on the diagnosis of pancreatic cancer.
目的探讨骨桥蛋白(OPN)在胰腺癌组织中表达的临床意义。
Objective To explore the expression and clinical significance of osteopontin (OPN) in patients with pancreatic cancer.
目的探讨血浆骨桥蛋白(OPN)水平与冠心病发病之间的关系。
Objective to probe into the relationship between plasma osteopontin (OPN) level and the development of coronary heart disease (CHD).
研究者也发现骨桥蛋白基因的表达触发了纤维蛋白酶原基因的表达。
The researchers also found that osteopontin gene expression triggered the expression of profibrogenic genes.
目的研究骨桥蛋白(OPN)在非小细胞肺癌(NSCLC)中的表达。
Objective To investigate the expression of osteopontin (OPN) in non-small cell lung cancer (NSCLC).
维生素d，维生素k，雌二醇和睾酮对结石模型大鼠肾骨桥蛋白表达的影响。
Effect of Vitamin d, Vitamin K, testosterone and estradiol on expressions of osteopontin in rat.
骨桥蛋白水平的增加被脂质颗粒提取物复制，并且被抗氧化剂维生素E阻止。
The increase in OPN levels was reproduced by the lipid extract of the particle and prevented by the antioxidant vitamin E.
骨形态发生蛋白2与骨桥蛋白检测：采用免疫组织化学染色与蛋白印迹方法。
The changes of BMP2 and osteopontin were detected by immunohistochemistry and Western blotting.
目的：评价骨桥蛋白(OPN)作为肿瘤血清标记物在胰腺癌诊断中的作用。
Objective: To evaluate the effect of osteopontin (OPN) as serum tumor marker on the diagnosis of pancreatic cancer.
目的研究骨桥蛋白在胃癌组织中的表达及其与诱导型一氧化氮合成酶表达的关系。
Objective To investigate the expression of osteopontin in gastric cancer and its correlation with inducible nitric oxide synthase.
杜仲对大鼠骨髓基质细胞骨桥蛋白和骨保护素表达的影响水提液与醇提液有区别吗？
Effect of eucommia bark on osteopontin and osteoprotegerin expressions in rat bone marrow stem cells: Is there any difference between water extract and methanol extract?
目的研究口腔白斑(olk)患者病损局部黏膜上皮细胞骨桥蛋白(OPN)表达情况。
Objective To explore the expression of osteopontin (OPN) in oral mucosal epithelium of oral local lesion in patients with oral leukoplakia (OLK).
骨桥蛋白（OPN）是分泌性细胞的细胞外基质蛋白，与细胞的多种生理功能关系密切。
Osteopontin(OPN) is an integrin-binding protein, believed to be involved in a variety of physiological cellular functions.
结论：冠心病患者中血浆骨桥蛋白水平明显升高，与冠状动脉病变的狭窄程度密切相关。
Conclusions: plasma OPN level was significantly elevated in CHD patients. The study indicated that plasma OPN levels might related to the severity of coronary artery lesions.
近年来的研究证实，骨桥蛋白在肝棘球蚴的外囊中大量表达，并在其形成过程中起重要作用。
Recent studies confirmed that osteopontin is highly expressed in liver hydatid cyst and may play an important role in cyst formation.
本文对骨桥蛋白在肿瘤中的信号转导、基因表达与调控以及肿瘤转移过程中的作用予以综述。
This article reviews its role in the signal transduction, expression and regulation in tumors and the roles in tumor metastasis.
骨桥蛋白是骨和牙的细胞外基质的主要成分，它的作用一直被认为是能通过多种受体来刺激细胞的活性。
Osteopontin is a protein that is a prominent part of the extracellular matrices of bones and teeth. It is known for its ability to stimulate cell activity through multiple receptors.
骨桥蛋白是一种具有多种功能的磷酸化糖蛋白，其中含有特异的与细胞黏附及迁移有关的GRGDS序列。
Osteopontin is a multifunctional phosphoprotein containing GRGDS sequence which functions in cell adhesion and chemotaxis.
骨桥蛋白是一种参与炎症、血管生成和转移的糖蛋白，研究发现其在发生癌症转移的病人中血中表达水平较高。
Osteopontin is a glycoprotein involved in inflammation, angiogenesis, and metastasis, and has been found in higher levels in cancer patients with metastatic disease.
骨桥蛋白是细胞外基质的重要组成部分，在细胞的黏附与迁移、组织的修复、细胞的信号转导中有重要的作用。
Osteopontin is a part of cell wall, which plays an important role in adherence, migration of cell, repair of tissue.
研究人员报告在20个肿瘤中有16检测到骨桥蛋白C（ 80 ％ ） ，但在22例正常标本中没有被检测到。
Osteopontin-c was detected in 16 of the 20 tumors (80%) and was undetectable in the 22 normal specimens, the researchers report.
方法采用免疫组化SP法检测23例原发性恶性黑素瘤、17例转移性恶性黑素瘤及20例色素痣中骨桥蛋白的表达。
Methods The expression of osteopontin was measured by immunohistochemistry SP technique in 23 primary cutaneous malignant melanoma, 17 metastatic melanoma and 20 nevus pigmentosus.
此外，骨分化相关特征基因骨桥蛋白OPN在复合支架上培养的细胞中的表达水平也明显高于纯壳聚糖上培养的细胞。
Simultaneously, the osteogenic gene osteopon tin(OPN)of cells cultured on composite scaffolds showed a higher expression level than that on chitosan scaffolds.
应用推荐