第一是儿童生来便带有的基因突变，接着需在儿童阶段有个触发事件，比如导致疾病的感染等。
The first is some kind of genetic mutation that a child is born with followed by a trigger in childhood such as an infection that results in the disease, she added.
KRAS基因突变在恶性肿瘤组织中频发，可预测非小细胞肺癌分子靶向治疗的疗效和预后，针对RAS基因的分子抑制剂研究仍处于初级阶段。
KRAS mutation frequency in tumor tissue, can be predicted non-small cell lung cancer molecular targeted therapy efficacy and prognosis, and molecular inhibitors of RAS genes is still in its infancy.
中国主要河流入海泥沙还具有明显的三个阶段变化特征，即分别在1968年和1984年前后发生了突变。
Periodical analysis showed that abrupt change of sediment load happened in 1968 and 1984, which divided the variation process of river sediment load into three stages.
遗传研究表明，白化转绿型突变性状受单隐性基因控制，并在幼苗阶段特异性表达。
Genetic study indicated that the mutated green-revertible albino leaf color trait specially expressed at seedling stage was controlled by a single recessive gene.
进一步分析表明，地球自转速度和太阳黑子周期长度的变化对高原及北半球本世纪气候的突变和阶段性变化起着重要的作用。
Further analyses show the variation of earth rotation rate and sunspot cycle length have important role on the climate abrupt change in the Qinghai-Xizang Plateau.
这些结果表明孢子不同萌发阶段对海水盐度突变的适应性不同。
The experiment result showed different development stage of Gloiopeltis tenax spores had different adaptability to the salinity change.
试件拉伸过程中塑性变形阶段内磁信号无较大数值变化，断裂后信号突变。
The magnetic signals were hardly varied during elastic and plastic deformation periods but changed after fracture rapidly.
方法用基因正向突变和周期阻断法微核实验作为启动阶段指标；
MethodsGene forward mutation method and micronuclei formation test were used to test the effects on the initiation of carcinogenesis;
另外，晶体生长过程中放肩阶段生长速率的突变则是导致孪晶形成的主要的外部因素。
Otherwise, the growth experiment results show that the abrupt change of growth rate during shoulder formation tends to cause twining.
在肿瘤治疗方面，人们以癌变过程中的不同突变基因为靶位，设计了许多反义抗肿瘤药物，其中部分已进入临床试验阶段。
For the treatment of cancer, a lot of antisense drugs have been designed, which target the genes involved in the pathogenesis of cancer. And some of them have been in clinical trials. The author...
在肿瘤治疗方面，人们以癌变过程中的不同突变基因为靶位，设计了许多反义抗肿瘤药物，其中部分已进入临床试验阶段。
For the treatment of cancer, a lot of antisense drugs have been designed, which target the genes involved in the pathogenesis of cancer. And some of them have been in clinical trials. The author...
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