为了利用这种基质金属蛋白酶，钱博士将他的荧光染料和一些正电荷一同连接在一个小的发夹形状的蛋白质分子的一端。
To make use of the MMPs, Dr. Tsien attaches his fluorescent dye, along with some positive charges, to one side of a small hairpin-shaped protein molecule.
有几种酶——如基质金属蛋白酶和胶原酶——可能派上用场，但矫枉过正也会有风险。
Several enzymes, such as matrix metalloproteinases and collagenases, might do the job, but overdoing it could be risky.
这是一系列尤其容易被基质金属蛋白酶切断的氨基酸(蛋白质的基石)序列。
This is a sequence of amino acids (the building blocks of proteins) that is particularly vulnerable to the cutting action of MMPs.
为了利用这种基质金属蛋白酶，钱博士将他的荧光染料和一些正电荷一同连接在一个小的发夹形状的蛋白质分子的一端。
To make use of the MMPs Dr Tsien attaches his fluorescent dye, along with some positive charges, to one side of a small hairpin-shaped protein molecule.
目的：探讨基质金属蛋白酶10 (MMP10)基因及其蛋白在人自然流产蜕膜中的表达水平及临床意义。
Objective: To discuss expression levels of MMP10 gene and protein in human spontaneous abortion deciduas and its significance in clinic.
基质金属蛋白酶(MMP)因其在肿瘤的生长、转移和血管生成等多个环节中发挥着重要作用而成为肿瘤治疗研究中引人注目的靶点。
Matrix metalloproteinases (MMPs) has been viewed as a promising target in tumor therapy due to their key role in tumor growth, angiogenesis, invasion and metastasis.
近几年来，基质金属蛋白酶因在肿瘤的生长、转移和血管生成等多个环节中发挥着重要作用而成为肿瘤治疗研究中引人注目的新靶点。
Matrix metalloproteinases (MMPs) has been viewed as a promising target in tumor therapy in recent years due to their key role in tumor growth, angiogenesis, invasion and metastasis.
目的：探讨结直肠癌环氧化酶- 2和基质金属蛋白酶- 7的表达与侵袭、转移的关系。
Objective: To investigate the expression of COX-2 and MMP-7 and their influence on invasion and metastasis in colorectal cancer.
结果患者血清基质金属蛋白酶-9水平高于健康对照组，差异有显著性意义（P<0.01）；
Results The serum levels of MMP-9 in IPF were significantly higher than that of healthy control, with significant difference (P<0.01).
目的探讨基质金属蛋白酶及其抑制因子与组织纤维化的关系。
Objective to discuss the relationship between matrix metalloproteinases and its tissue inhibitors and tissue fibrosis.
目的研究纤维连接蛋白(FN)、层黏连蛋白(LN)、细胞外基质金属蛋白酶诱导因子(EMMPRIN)在食管癌的表达，探讨其临床意义。
Objective To study the expression and clinical significance of fibronectin (FN), laminin (LN) and extracellular matrix metalloproteinase inducer (EMMPRIN) in esophageal carcinoma.
感染引发早产的机制与前列腺素的合成、细胞因子的异常分泌、基质金属蛋白酶活性增加等有关。
The mechanism of premature delivery caused by infection involves in increased prostaglandin synthesis, abnormal secretion of cytokines and increased activity of matrix metalloproteinases.
在创面的愈合过程中，生长因子与基质金属蛋白酶的相互调节是保证创面微环境的稳定、促进创面愈合的主要因素。
Therefore, the adjustment between the growth factor and matrix metalloproteinase is the key to protect the stabilization of micro-environment and to accelerate the wound healing.
目的：评价基质金属蛋白酶抑制剂临床应用的疗效与安全性。
OBJECTIVE: to evaluate the efficiency and safety of matrix metallo-proteinase inhibitor in clinical application.
方法采用酶联免疫吸附法对40例特发性肺纤维化患者和30例健康人血清基质金属蛋白酶- 9进行测定。
Methods The serum level of MMP-9 in 40 patients with IPF and 30 healthy subjects was measured by ELISA.
明胶酶谱法测量血液循环中基质金属蛋白酶- 9 (MMP - 9)水平。
Gelatin zymography was used to measure blood levels of circulating matrix metalloproteinase-9 (MMP-9).
目的：探讨基质金属蛋白酶- 9 (MMP - 9)在心肌再灌注损伤中的作用。
AIM: To study the roles of matrix metalloproteinase-9 (MMP-9) in the myocardial reperfusion injury.
目的探讨组织蛋白酶D（CD）与基质金属蛋白酶-9（MMP-9）在人类口腔鳞癌（OSCC）中的表达意义。
Objective To investigate the expression and the significance of cathepsin D(CD) and matrix metalloproteinase-9(MMP-9) in oral squamous cell carcinoma(OSCC).
布洛芬对软骨降解及基质金属蛋白酶13和组织蛋白酶k水平无明显影响。
Ibuprofen had no obvious effect on articular cartilage degradation and decreasing the levels of matrix metalloproteinase 13 and cathepsin K.
目的探讨膜型基质金属蛋白酶-1在人脑胶质瘤中的表达及其与肿瘤生物学行为和预后的关系。
Objective To investigate the expression of membrane type-1 matrix metalloproteinase(MT1-MMP) in human glioma and its relationship to clinicopathological factors and prognosis of glioma patients.
目的研究基质金属蛋白酶- 9 (MMP - 9)和基质金属蛋白酶抑制物- 1 (TIMP - 1)在早孕期蜕膜和绒毛中的表达特点。
Objective to study the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) proteins in the decidua and villi of the early pregnancy.
目的：探讨碱性成纤维细胞生长因子对基质金属蛋白酶表达的影响及其在球囊术后再狭窄中的作用。
Objective: To investigate the effect of basic fibroblast growth factor on matrix metalloproteinases and restenosis after PTCA .
近年来的研究表明，血管内皮生长因子、基质金属蛋白酶- 2和基质金属蛋白酶- 8在动脉粥样硬化斑块不稳定中起着重要作用。
Recent studies have suggested that vascular endothelial growth factor, matrix metalloproteinase-2 and-8 play important roles in the instability of atherosclerotic plaques.
目的：观察基质金属蛋白酶- 7 (MMP - 7)蛋白在鼻咽癌中的表达及与肿瘤侵袭转移的关系。
Objective: To observe the expression of matrix metalloproteinase-7 (MMP-7) in nasopharyngeal carcinoma and it's significance in metastasis.
基质金属蛋白酶是一类结构相关的内肽酶家族，能够降解细胞外基质成分。
The matrix metalloproteinases are a family of structurally related endopeptidases, they have the ability to degrade all components of extracellular matrix.
目的：构建基质金属蛋白酶9靶向的RNA干扰质粒载体，观察其对小鼠巨噬细胞基质金属蛋白酶9基因表达的沉默作用。
AIM: to construct plasmid vector of RNA interference specific for matrix metalloproteinases (MMP) -9 and observe the silencing effect on gene expression of MMP-9 in macrophage of mice.
目的：检测肝细胞癌患者血清血管内皮生长因子与基质金属蛋白酶- 9含量并分析与临床分期的相关性。
Objective to detect the concentration of serum vascular endothelial growth factor and matrix metalloproteinase-9 in hepatocellular carcinoma and analyze their relation with the clinical stages.
目的：探讨层粘连蛋白(LN)、基质金属蛋白酶9 (MMP 9)在卵巢粘液性肿瘤中的表达以及与临床病理因素和预后的关系。
Objective: to study the expression of laminin (LN) and matrix metalloproteinases-9 (MMP-9) and its association with clinicopathological factors and prognosis in mucinous tumors of the ovary.
基质金属蛋白酶家族是锌依赖蛋白酶，是参与正常细胞外基质代谢的重要酶类。
Matrix metalloproteinases(MMPs )are a family of zinc-dependent proteinases involved in the degradation of the extracellular matrix.
目的探讨基质金属蛋白酶9（MMP9）及组织型基质金属蛋白酶抑制因子1（TIMP1）在大鼠感染性脑水肿中的表达及意义。
Objective To explore the expression and significance of matrix metalloproteinase 9(MMP9) and tissue inhibitor of metalloproteinase 1(TIMP1) in rats with infectious brain edema.
应用推荐