但这种给药方式使血药浓度波动很大，不利于临床的有效治疗。
But the administration makes the plasma concentration change enormously, which is not suitable in treatment.
结论：两种制剂具生物等效性，且缓释片比常释片有峰谷浓度差异小、血药浓度波动幅度小的特点。
CONCLUSION: The two formulations were bioequivalent and the sustained release tablet showed smaller difference between C max and C min and smaller DF compared with the ordinary tablet.
前言：目的：探讨影响丙戊酸钠血药浓度波动的因素，提高丙戊酸钠血药浓度检测的有效性及可利用性。
OBJECTIVE: to observe the factors that influence the fluctuation of serum concentrations of valproic acid and to improve the effectiveness and usefulness of monitoring the serum concentration.
结论漂浮胶囊具有缓释效果，与普通片生物利用度相当，在服药次数减少的情况下，血药浓度波动小于普通片。
CONCLUSION FRSC had good sustained release effect and the fluctuation was lower when the dosing interval longer than ct.
本发明为复方控释制剂，血药浓度波动小、降低了副作用、提高疗效、一天仅服一次、提高了患者的顺应性，具有显著的优点。
The compound controlled releasing preparation has the obvious advantages of small blood medicine concentration fluctuation, less side effect, raised curative effect and raised patient's compliance.
结论老年心衰病人的个体药代动力学参数波动范围大，个体差异更为突出，临床应在血药浓度监测的基础上实行最佳个体化给药。
Conclusions there is a significant individual variation in the pharmacokinetic parameters, therefore, the dose should be individualized on the basis of blood drug concentration monitoring.
结论老年心衰病人的个体药代动力学参数波动范围大，个体差异更为突出，临床应在血药浓度监测的基础上实行最佳个体化给药。
Conclusions there is a significant individual variation in the pharmacokinetic parameters, therefore, the dose should be individualized on the basis of blood drug concentration monitoring.
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