本文综合近年文献,对微透析技术的基本原理以及在抗菌药物药动学和药效学研究中的应用作一综述。
In this paper, basic principle and application of microdialysis in pharmacokinetic and pharmacodynamic studies of antimicrobials are reviewed.
结果:葡萄柚汁可改变许多药物的药动学,使血药浓度升高,引起有临床意义的食物-药物相互作用。
Results: Grapefruit juice can change the pharmacokinetics of a broad range of medicines and increases the blood concentrations of drugs, therefore, induces clinical food drug interactions.
可以利用药物来改变某种毒剂的药动学性质。
Drugs may be utilized to alter the pharmacokinetic profile of a toxicant.
现对其作用机制、药动学、临床应用、不良反应、药物相互作用等做一综述。
This paper summarizes the mechanism, pharmacokinetics, clinical application, adverse reactions and drug interactions of lenalidomide.
目的介绍老年期药动学及药效学变化及合理使用药物。
OBJECTIVE To introduce the pharmacokinetics and pharmacodynamics of gerontic and rational administration of drug.
目的建立单室模型药物血管外多剂量给药的吸收和清除药动学的残数法计算方法。
Objective To establish a feathering method for processing the pharmacokinetic parameters of mono-compartment drugs administered by non-parenteral route by repeated doses.
药物浓度对时间数据作房室模型和统计矩解析,并求出相应的药动学参数。
Analysis of the data was executed by compartmental model and statistical moment calculation from which pharmacokinetic parameters were obtained.
在药物开发初期,就将药动学性质不佳的新化学实体剔除出去具有十分重要的意义。
It is of great importance to identify the new chemical entity (NCE) with poor pharmacokinetic properties early in drug discovery pipeline.
综述托拉·塞米的药理作用、药动学、临床应用、药物不良反应和药物经济学。
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and pharmaco economics of torasemide are reviewed.
许多药物相互作用可分为药效学的、药动学的及药剂学的三种。
Most drug interactions can be classified as pharmacodynamic, pharmacokinetic, or pharmaceutical.
本发明应用了药动学模型和药效学模型来确定最适的药物制剂和最适的施用参数。
A pharmacokinetic and pharmacodynamic model is employed to determine optimum drug formulations and optimum parameters for administration.
对新型非典型抗精神病药帕利哌酮、伊洛哌酮和阿塞那平的作用机制、药动学、临床应用、药物相互作用及不良反应等进行简要介绍。
The mechanism of action, pharmacokinetics, clinical application, drug interactions, and adverse reactions of new atypical antipsychotics paliperidone, iloperidone, and asenapine were reviewed.
采用固相萃取-高效液相色谱法测定大鼠血浆中药物浓度,计算药动学参数和生物利用度。
The blood samples were collected from the rats and the plasma concentration was measured by SPE-HPLC. The pharmacokinetic parameters and absolute bioavailability were evaluated.
美索·巴莫是促进骨骼肌疼痛患者恢复的一种很好的辅助药物,现对其药动学、合成工艺、药理作用、临床应用及安全性等做一综述。
Methocarbamol is a useful adjunct in improving patient recovery. In this article, we summarized its pharmacokinetics, synthesis, pharmacological effect, clinical use and safety.
本文就格列奈类药物的药动学性质及与其他药物的药动学相互作用作一综述。
Pharmacokinetics of glinides and pharmacokinetic interactions with other drugs are reviewed in this paper.
文中对维拉唑酮的药理作用、药动学、临床评价、安全性以及药物相互作用等进行了综述。
The pharmacology, pharmacokinetics, clinical evaluation, safety and drug interactions of vilazodone were reviewed in this paper.
目的:采用高效液相-荧光色谱法测定人血清中拉呋替丁药物浓度,研究临床推荐剂量下的健康人体药动学。
OBJECTIVE To determine prazosin hydrochloride in human plasma by HPLC-MS method, and to investigate its pharmacokinetics and bioequivalance.
目的:采用高效液相-荧光色谱法测定人血清中拉呋替丁药物浓度,研究临床推荐剂量下的健康人体药动学。
OBJECTIVE To determine prazosin hydrochloride in human plasma by HPLC-MS method, and to investigate its pharmacokinetics and bioequivalance.
应用推荐