方法：以包封率和平均粒径为评价指标，采用星点设计-效应面法优化醇质体处方中大豆磷脂、药物和无水乙醇的最佳配比。
METHODS Taking encapsulated ratio and average diameter as evaluation index to optimize the best matching of soybean phospholipid, drug and absolute alcohol in ethosomes.
方法以微囊的药物包封率为制备工艺优化指标，利用复凝聚法，通过正交实验得出微囊的最佳制备工艺条件。
Methods the orthogonal experimental design adopting the standard of drug encapsulation was applied to optimize the preparation procedure of the microcapsules by the complex coacervation method.
不同制备条件对微球药物包封率的影响程度较小。
The drug incorporation efficiency was affected in a narrow range by the conditions.
利用扫描电镜和紫外光谱考察了内相聚合物浓度和搅拌速度对微球粒径和药物包封率的影响。
The effects of polymer concentration and agitation rates on the size of microspheres and drug incorporation efficiency were studied by scanning electronic microscopy (SEM) and UV-spectrophotometry.
结果：通过调节药物浓度和不同高分子组合筛选出突释小，包封率高且缓慢释放的处方。
Results: By adjusting LDME concentration and different polymer combinations, we achieved microspheres with high encapsulation efficiency, low initial burst and sustained release.
本发明制备工艺简单，所 得纳米粒子粒径均匀，粒度分布较窄，对疏水性药物有较高的载药量和包封率。
The invention has simple process, uniform grain diameter, narrow graininess distribution, high carrier and packing rate on hydrophobic drug.
方法：以微囊的药物包封率为制备工艺优化指标，利用复凝聚法，通过正交实验得出微囊的最佳制备工艺条件。
Method: the orthogonal experimental design adopts the standard of drug encapsulation and optimizes the preparation procedure of the microcapsules by the complex coacervation method.
考察了药物与磷脂的复合率，磷脂复合物脂质体的包封率，粒径大小和分布，以及体外释药特性。
The drug loading rate, encapsulation efficiency, particle distribution and in vitro release of Lac-NCTD from liposomes were investigated, respectively.
本发明方法建立的给药系统具有载药范围广、药物包封率高及稳定性好的特点，并可降低药物毒性。
The drug delivery system established by the method has the characteristics of wide drug-carrying range, high drug envelopment rate and good stability and can reduce drug toxicity.
目的 进行新型抗癌药物盐酸拓扑替康的脂质体制备研究，以期得到具有较高包封率的制备方法。
OBJECTIVE To study the best preparation method of liposomal topotecan(TPT) hydrochloride by comparing the entrapment efficiencies of different methods.
提 高了纳米粒子的载药量及包封率，控制了疏水性药物的突释现象。
The invention improves the carrier and packing rate of nanometer particles, and controls the instant release condition of hydrophobic drug.
结果鱼精蛋白凝聚法可以准确测定不同溶解性质药物脂质体的包封率；
The encapsulation efficiency determined by the sephadex chromatography method and protamine aggregation method was compared.
结果鱼精蛋白凝聚法可以准确测定不同溶解性质药物脂质体的包封率；
The encapsulation efficiency determined by the sephadex chromatography method and protamine aggregation method was compared.
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