本文对近期所了解的细胞核受体调节转录的分子机制进行综述。
This review addresses recent advances in our understanding of the molecular mechanisms regulating transcription of these nuclear receptors.
HR蛋白是细胞核受体辅阻遏物的发现证明HR蛋白是通过在毛发周期中调节基因表达来发挥作用的。
The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression.
细胞表面的受体对外界信息的相应反应就是将信息以信号的形式传递给启动基因表达和控制细胞功能的细胞核。
In response to such incoming information, receptors on a cell's surface send signals to the nucleus that tweak gene expression and control cellular function.
PPAR激动剂，是细胞核激素受体家族转录因子的一个成员，被广泛用来治疗II型糖尿病，而且相对无毒。
Agonists of PPAR, a member of the nuclear hormone receptor family of transcription factors, are widely used in the treatment of type II diabetes and are relatively non-toxic.
目的：研究表皮生长因子受体和增殖细胞核抗原在胃肿瘤中的表达及其临床意义。
Objective: To study the expression of EGFR and PCNA protein in human gastric neoplasm and its clinical significance.
目的探讨补锌对甲状腺功能低下大鼠肝细胞核T3受体特性的影响。
Objective To observe the effects of zinc (Zn) on the character of liver nuclear T3 receptors in hypothyroid rats.
结果：神经胶质瘤细胞株u343表达死亡受体DR5, DR 5分布于细胞内细胞核的周围。
Results: The expression of death receptor 5 (DR5) was certificated in U343, DR5 appeared to be located in intracellular perinuclear compartment.
在心肌细胞中，T3结合到细胞核中的甲状腺激素受体，其依次结合靶基因调节区中的甲状腺激素反应元件以调节转录。
In the cardiomyocyte, T3 binds to thyroid hormone receptors in the nucleus, which in turn bind to thyroid hormone response elements in the regulatory regions of target genes to regulate transcription.
目的探讨层连接蛋白受体、E -钙粘附蛋白和增殖细胞核抗原在胃癌中的表达及其意义。
Objective to investigate the expression and Significance of Laminin receptor (LN-R), E-cadherin (E-cad) and proliferation cell nuclear antigen (PCNA) in patients with gastric carcinoma.
跨膜受体可从膜表面进入细胞核内直接调控细胞的生命活动，但其核转位的途径至今尚无定论。
Although transmembrane receptors from cell surface to nucleus can generally regulate the cellular life activities, their pathways of nuclear translocation still remain to be elucidated.
研究结果提示，精索静脉曲张睾丸功能障碍可能与血清睾酮浓度低下及睾丸细胞核雄激素受体反应异常有关。
The authors suggest that the disturbed function of testes in rats with varicocele may be related to lower values of serum testosterone and abnormal reaction of NAR in testes.
这些复杂的细胞结构通过细胞表面与细胞核内的受体、信号转导途径等实现对刺激信号的吸收并根据不同的微环境做出相应的应答。
Furthermore, through cell surface or nucleus receptors and signal transduction pathway, cell can absorb various stimulation, at the same time, react according to the different microenvironment.
目的探讨白三烯（LT）B4能否不依赖细胞核因子资B受体激活剂配体（RANKL）直接促进人破骨细胞的分化和激活。
Objective To determine whether leukotriene B4 (LTB4) could directly stimulate human osteoclast differentiation and activation independent of RANKL (ODF).
PR在神经细胞核中的定位表明其为核受体，很有可能在基因水平上参与拟穴青蟹视神经节的生理活动调节。
PR is a nuclear receptor which may mediate the physiological activities of optic ganglia via nuclear receptor in gene level.
PR在神经细胞核中的定位表明其为核受体，很有可能在基因水平上参与拟穴青蟹视神经节的生理活动调节。
PR is a nuclear receptor which may mediate the physiological activities of optic ganglia via nuclear receptor in gene level.
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